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Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Open accessAbstract
Transforming Fat to Thin: How much does the microbiota influence the host's phenotype? Ridaura et al. ( 1241214 ; see the Perspective by Walker and Parkhill ) obtained uncultured fecal microbiota from twin pairs discordant for body mass and transplanted them into adult germ-free mice. It was discovered that adiposity is transmissible from human to mouse and that it was associated with changes in serum levels of branched-chain amino acids. Moreover, obese-phenotype mice were invaded by members of the Bacteroidales from the lean mice, but, happily, the lean animals resisted invasion by the obese microbiota.
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In the citing paper
“This is thought to be driven by an expansion in pro-inflammatory species of bacteria, such as E. coli, and a depletion of anti-inflammatory bacteria such as Faecalibacterium prausnitzii [133,134].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [133]
Experimental — accuracy not yet measuredIn the citing paper
“Furthermore, athletes have an enriched profile of SCFAs, previously associated with numerous health benefits and a lean phenotype.[33][34][35]”
From The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level (2018) · cites this paper as [34]
In the citing paper
“The same clusters are observed when correlating with individual taxa, in support of previously observed links between SCFAs and numerous metabolic benefits and a lean phenotype.[33][34][35]”
From The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level (2018) · cites this paper as [34]
In the citing paper
“Studies with gnotobiotic mice colonized with the microbiota of lean or obese twins have also shown that this phenotype is also transmissible [7].”
From Intestinal Microbiota Is Influenced by Gender and Body Mass Index (2016) · cites this paper as [7]
In the citing paper
“This observation also holds true when the microbiota from obese or lean humans is transferred to germ-free mice (Ridaura et al., 2013; Tremaroli et al., 2015).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Ridaura et al., 2013
In the citing paper
“altering the gut microbiome in humans and mice has shown improvement in metabolic syndrome.”
From The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids (2015) · cites this paper as [14]
In the citing paper
“reports of alterations in the gut microbiota of obese people4,13–15, which confer the obese or adiposity phenotypes when transferred to mice14,16”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [14]
In the citing paper
“Importantly, the lean microbiota could only invade and prevent increased adiposity when the recipient mice consumed a diet that was low in fat and high in fruits and vegetables.”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [14]
In the citing paper
“bacterial representatives from the microbiota of lean individuals were associated with an increased production of short-chain fatty acids”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [14]
In the citing paper
“the microbiota of obese individuals had an increased abundance of genes that are involved in biosynthesis of branched-chain amino acids, which are associated with impaired sensitivity to insulin14.”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [14]
In the citing paper
“Transfer of gut microbiota from lean and obese individuals can recapitulate the metabolic phenotype in ex-germ free mice.14”
From Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook (2015) · cites this paper as [14]
In the citing paper
“Several lines of evidence support the role of gut microbiota in obesity.”
From Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook (2015) · cites this paper as [14]
In the citing paper
“Multiple human and animal studies have linked increased branched-chain amino acids (BCAAs) with insulin resistance and type 2 diabetes in obese groups [150,151,152,153].”
From Impact of Protein Intake in Older Adults with Sarcopenia and Obesity: A Gut Microbiota Perspective (2020) · cites this paper as [151]
In the citing paper
“experiments have shown that the condition can be transferred from obese mice or humans to healthy mice via conventionalization (i.e. microbiota transfer by feeding fecal material) [64, 65].”
From Antibiotic-Induced Changes in the Intestinal Microbiota and Disease (2016) · cites this paper as [65]
In the citing paper
“Gut microbiota plays a key role in the pathogenesis of obesity.”
From Antibiotic-Induced Changes in the Intestinal Microbiota and Disease (2016) · cites this paper as [65]
In the citing paper
“Furthermore, athletes have an enriched profile of SCFAs, previously associated with numerous health benefits and a lean phenotype [61–63].”
From The athletic gut microbiota (2020) · cites this paper as [63]
In the citing paper
“obese mice fed a low saturated fat, high fruit and vegetable diet can take on microbiota characteristics of lean mice [63].”
From The athletic gut microbiota (2020) · cites this paper as [63]
In the citing paper
“mice consuming this diet regardless of lean or obese state gained less fat mass compared to lean and obese mice fed a high-saturated fat, low fruit and vegetable diet, typical of a Westernized diet.”
From The athletic gut microbiota (2020) · cites this paper as [63]
In the citing paper
“in support of purported links between SCFAs and numerous metabolic benefits and a lean phenotype [61–63].”
From The athletic gut microbiota (2020) · cites this paper as [63]
In the citing paper
“transplantation of the fecal microbiota from patients with obesity, steatosis or type 2 diabetes can partly reproduce the donor’s metabolic phenotype in mouse recipients [4–7].”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [4]
In the citing paper
“While human and animal studies have established the ability to successfully populate the oral cavity or gastrointestinal tract with specific strains, combinations of bacteria, or bacteria genetically modified to produce enzymes or metabolites[74,404–407]”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [404]
In the citing paper
“similar transplantation of the microbiome from the obese but not normal-weight twin, to healthy germ-free mice, also promotes adiposity and perturbs glucose metabolism [9].”
From Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals (2016) · cites this paper as [9]
In the citing paper
“transplanting the microbiota of genetically obese ob/ob mice or obese humans to lean germfree mice increases the adiposity of the recipient mice [8], [9]”
From Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals (2016) · cites this paper as [9]
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Metadata
- Authors
- Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., Muehlbauer, M. J., Ilkayeva, O., Semenkovich, C. F., Funai, K., Hayashi, D. K., Lyle, B. J., Martini, M. C., Ursell, L. K., Clemente, J. C., Van Treuren, W., Walters, W. A., Knight, R., Newgard, C. B., Heath, A. C., & Gordon, J. I.
- Affiliations
- Washington University in St. Louis (US)
- Centre National de la Recherche Scientifique (FR)
- University of Copenhagen (DK)
- Duke Medical Center (US)
- Mondelēz International (United States) (US)
- Kraft Foods Group, Glenview, IL 60025, USA.
- University of Colorado Boulder (US)
- Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.
- Howard Hughes Medical Institute (US)
- Corresponding author
- Gordon, Jeffrey I.
- ORCID
- Ridaura, Vanessa K.
- Faith, Jeremiah J.
- Rey, Federico E.
- Cheng, Jiye
- Duncan, Alexis E.
- Kau, Andrew L.
- Griffin, Nicholas W.
- Lombard, Vincent
- Henrissat, Bernard
- Bain, James R.
- Muehlbauer, Michael J.
- Ilkayeva, Olga
- Semenkovich, Clay F.
- Funai, Katsuhiko
- Lyle, Barbara J.
- Walters, William A.
- Knight, Rob
- Newgard, Christopher B.
- Heath, Andrew C.
- Gordon, Jeffrey I.
- Venue
- Science
- Published
- 2013-09-06
- Volume
- 341
- Issue
- 6150
- Pages
- 1241214-1241214
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3829625
- OpenAlex
- W1993399595
- Cited by
- 3,788
- References
- 76
- Citations by year
- 2026: 169 · 2025: 209 · 2024: 260 · 2023: 289 · 2022: 329 · 2021: 422 · 2020: 387 · 2019: 322 · 2018: 357 · 2017: 306 · 2016: 267 · 2015: 264 · 2014: 174 · 2013: 29
- FWCI
- 109.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Crohn's and Colitis Foundation
- National Institute on Alcohol Abuse and Alcoholism (K05AA017688)
- National Institute on Aging (P30AG028716)
- National Institute of General Medical Sciences (T32GM008759, T32GM142607)
- National Institute of Diabetes and Digestive and Kidney Diseases (K01DK095774, P01DK058398, DK078669, DK-58398, P01DK078669, R01DK076729, DK 70977, F32DK091044, R01DK070977, P30DK056341, P30DK020579)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, obesity, twin discordance, fecal microbiota transplantation, germ-free mice, body composition, fat mass, Bacteroidetes, diet-microbiome interactions, saturated fat, fruit and vegetable intake, metabolic phenotypes
- MeSH terms
- Adult, Animals, Cecum, Feces, Female, Germ-Free Life, Humans, Mice, Inbred C57BL, Mice, Obese, Obesity, Thinness, Twins, Weight Gain, Diet, Fat-Restricted, Bacteroidetes, Gastrointestinal Tract, Adiposity, Mice, Metagenome, Metabolome, Young Adult
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