The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Open accessAbstract
In non-human mammals, the neuropeptide oxytocin is a key mediator of complex emotional and social behaviors, including attachment, social recognition, and aggression. Oxytocin reduces anxiety and impacts on fear conditioning and extinction. Recently, oxytocin administration in humans was shown to increase trust, suggesting involvement of the amygdala, a central component of the neurocircuitry of fear and social cognition that has been linked to trust and highly expresses oxytocin receptors in many mammals. However, no human data on the effects of this peptide on brain function were available. Here, we show that human amygdala function is strongly modulated by oxytocin. We used functional magnetic resonance imaging to image amygdala activation by fear-inducing visual stimuli in 15 healthy males after double-blind crossover intranasal application of placebo or oxytocin. Compared with placebo, oxytocin potently reduced activation of the amygdala and reduced coupling of the amygdala to brainstem regions implicated in autonomic and behavioral manifestations of fear. Our results indicate a neural mechanism for the effects of oxytocin in social cognition in the human brain and provide a methodology and rationale for exploring therapeutic strategies in disorders in which abnormal amygdala function has been implicated, such as social phobia or autism.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Neuroimaging studies in humans have largely substantiated this view.”
From Could intranasal oxytocin be used to enhance relationships? Research imperatives, clinical policy, and ethical considerations (2013) · cites this paper as [41]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Indeed, previous published OT studies have also compared images of landscapes to faces [16], [34].”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [16]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“It is known, however, that OTs effects in the olfactory bulb on social recognition are mediated by norepinephrine [75, 76].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [76]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“as well as in counteracting fear (Kirsch et al. 2005)”
From Natural Selection, Childrearing, and the Ethics of Marriage (and Divorce): Building a Case for the Neuroenhancement of Human Relationships (2012) · cites this paper as Kirsch et al. 2005
The cited source says what the claim attributes to it.
In the citing paper
“This finding is in line with the anxiolytic action of OT via inhibiting amygdala responses to threatening stimuli (Kirsch et al., 2005; Petrovic et al., 2008).”
From Oxytocin facilitates approach behavior to positive social stimuli via decreasing anterior insula activity (2018) · cites this paper as Kirsch et al., 2005
The cited source says what the claim attributes to it.
In the citing paper
“Administration of oxytocin, a hormone associated with social bonding, correlated with a decrease of amygdala activity following exposure to interpersonally threatening visual stimuli (angry or afraid faces; Charuvastra & Cloitre, 2008; Kirsch et al., 2005).”
From Sudanese Refugees in Cairo, Egypt: A Randomized Controlled Trial of Interpersonal Psychotherapy for Trauma, Depression and Interpersonal Violence: (517292011-807) (2009) · cites this paper as Kirsch et al., 2005
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Mothers who observe photographs of their own infants compared against matched controls show heightened activation in brain areas rich in oxytocin, vasopressin, and dopamine neuroreceptors [41, 42].”
From Could intranasal oxytocin be used to enhance relationships? Research imperatives, clinical policy, and ethical considerations (2013) · cites this paper as [41]
Experimental — accuracy not yet measuredIn the citing paper
“Together, these previous findings suggest that dampened neural response to social threat leads to greater sociability.”
From Effects of MDMA on sociability and neural response to social threat and social reward (2009) · cites this paper as Kirsch et al. 2005
In the citing paper
“OT administration also reduces amygdala activation in response to threatening social stimuli (Kirsch et al. 2005)”
From Effects of MDMA on sociability and neural response to social threat and social reward (2009) · cites this paper as Kirsch et al. 2005
In the citing paper
“neuroimaging evidence suggests that the administration of OXT inhibits amygdala activation (Domes et al., 2007b;Kirsch et al., 2005;Singer et al., 2008)”
From Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear (2017) · cites this paper as Kirsch et al., 2005
In the citing paper
“while it has been demonstrated that OXT decreases amygdala activity in response to fear in men (Kirsch et al., 2005), it appears to increase amygdala activity to similar stimuli in women (Domes et al., 2010).”
From Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear (2017) · cites this paper as Kirsch et al., 2005
In the citing paper
“separate OXT-application studies in humans have indicated that there may be differential amygdala reactivity to fearful faces and fearful/threatening scenes in men (14, 15) and women (16, 17).”
From Oxytocin, the peptide that bonds the sexes also divides them (2016) · cites this paper as [15]
In the citing paper
“Previous studies on amygdala responses to fearful faces and fearful/threatening scenes (14 -17, 30) and social risk (31) have also indicated that OXT may induce sex-dependent changes in amygdala activation to emotional stimuli.”
From Oxytocin, the peptide that bonds the sexes also divides them (2016) · cites this paper as [15]
In the citing paper
“On the other hand, there are several reports that OT reduces social anxiety by attenuating the amygdala response to fearful social signals (Kirsch et al., 2005;Baumgartner et al., 2008).”
From The effect of oxytocin on cooperation in a prisoner's dilemma depends on the social context and a person's social value orientation (2014) · cites this paper as Kirsch et al., 2005
In the citing paper
“decrease amygdala activation to fearful faces (21–23)”
From Oxytocin and the development of parenting in humans (2010) · cites this paper as [22]
In the citing paper
“Intranasal OT administration in FXS may work mechanistically by dampening amygdala reactivity toward socially threatening and anxiety-provoking stimuli (Kirsch et al., 2005; Petrovic et al., 2008), decreasing HPA axis activation, and increasing social motivation (Witt et al., 1992).”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Kirsch et al., 2005
In the citing paper
“Effects of intranasal OT have also been demonstrated with functional neuroimaging (Kirsch et al., 2005)”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Kirsch et al., 2005
In the citing paper
“The hypothesis that central OTR activation modulates correlated activity across distributed brain networks is consistent with continually emerging data from experiments in primates.”
From Oxytocin receptors modulate a social salience neural network in male prairie voles (2017) · cites this paper as Kirsch et al., 2005
In the citing paper
“For example, fMRI experiments in both rhesus macaques and humans have found that intranasal OT administration modulates correlated fluctuations in BOLD responses across limbic, striatal, cortical, and/or brainstem nuclei during a variety of social contexts (Bethlehem et al., 2013; Gorka et al., 2015; Kirsch et al., 2005; Liu et al., 2015; Riem et al., 2012; Rilling et al., 2012).”
From Oxytocin receptors modulate a social salience neural network in male prairie voles (2017) · cites this paper as Kirsch et al., 2005
In the citing paper
“Consistent with this evidence, functional magnetic imaging (fMRI) studies with healthy volunteers have shown that intranasal OXT administration dampens amygdala reactivity to threatening facial expressions (Domes et al, 2007;Kirsch et al, 2005), and naturalistic social interactions (Baumgartner et al, 2008).”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Kirsch et al, 2005
In the citing paper
“Meanwhile, Kirsch et al (2005) found that OXT reduced functional coupling between the amygdala and the brainstem.”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Kirsch et al, 2005
In the citing paper
“The fMRI scan began 45 min post inhalation of OXT or PBO, and lasted for 30 min.This time frame is consistent with prior OXT administration studies and coincides with the expected timing of OXT's physiological effects (eg, Domes et al, 2007;Kirsch et al, 2005).”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Kirsch et al, 2005
In the citing paper
“The EFMT task has previously been described in detail elsewhere (Labuschagne et al, 2010), and has been used in previous pharmaco-fMRI studies to probe drug effects on amygdala activation (Kirsch et al, 2005;Paulus et al, 2005;Phan et al, 2008;Labuschagne et al, 2010) and amygdala functional connectivity (Gorka et al, 2013).”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Kirsch et al, 2005
In the citing paper
“Intranasal OT reduces amygdala reactivity in men (5, 7)”
From Oxytocin receptors in the anteromedial bed nucleus of the stria terminalis promote stress-induced social avoidance in female California mice (2018) · cites this paper as [7]
In the citing paper
“In agreement, neuroimaging studies demonstrate that intranasal administration of oxytocin attenuates amygdala activation following stressful and fearful stimuli (Baumgartner et al., 2008; Domes et al., 2007; Kirsch et al., 2005; Labuschagne et al., 2010).”
From Effect of oxytocin on craving and stress response in marijuana-dependent individuals: A pilot study (2013) · cites this paper as Kirsch et al., 2005
In the citing paper
“In this context, the insula17 as well as the amygdala seem to be key target regions in the brain, with oxytocin modulating amygdala responsiveness to emotional faces18–22 or social stimuli in general23.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [20]
In the citing paper
“These studies have repeatedly demonstrated decreased amygdala activation, which has been interpreted as a neural mechanism underlying oxytocin’s anxiolytic effects18,20,21.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [20]
In the citing paper
“This is also agreement with decreasing amygdala activation to fearful faces in healthy (45), as well as anxious (46), humans with OT administration.”
From Neuroendocrinology of Parental Response to Baby‐Cry (2011) · cites this paper as [45]
In the citing paper
“This reduction in anxiety and fear is in line with an increasing body of evidence showing that IN-OT reduces the BOLD activity of the amygdala region in response to faces (Domes et al. 2007a; Kanat et al. 2015a, b; Kirsch et al. 2005).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Kirsch et al. 2005
In the citing paper
“More specific, intranasal oxytocin administration decreased functional connectivity between the amygdala and the brainstem during exposure to fearful social faces (Kirsch et al., 2005).”
From Oxytocin effects on complex brain networks are moderated by experiences of maternal love withdrawal (2013) · cites this paper as Kirsch et al., 2005
In the citing paper
“A pragmatic approach guided by prior fMRI OT research (Domes et al., 2007(Domes et al., , 2010;;Kirsch et al., 2005;Lischke et al., 2012) was taken for sample size determination reflecting the phase 1 status of OT administration using the Breath Powered device and the complex nature of the study design.”
From Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial (2016) · cites this paper as Kirsch et al., 2005
In the citing paper
“In humans, OT is mostly known for its functions in childbirth and breastfeeding, but it can also alleviate social stress, for example, by lowering salivary cortisol levels 4 , increasing parasympathetic control of the heart 5 , and attenuating amygdala activation in response to seeing faces 6,7 .”
From A registered replication study on oxytocin and trust (2020) · cites this paper as [6]
In the citing paper
“modulates neural circuitry for social cognition in humans,15”
In the citing paper
“Accumulating evidence from studies in animals and in healthy and psychiatric human populations shows that oxytocin administration may modulate glucocorticoid (16) and autonomic stress reactivity (17), dampen anxiety and neural threat processing (18,19), and beneficially impact socioemotional processes and prosocial behavior (20,21) [but see also (22,23) for seemingly nonprosocial effects].”
From Intranasal Oxytocin to Prevent Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial in Emergency Department Patients (2017) · cites this paper as [18]
In the citing paper
“In addition, intranasal oxytocin also dampened the central fear response by lowering amygdala activity [44-46] and potentially enhancing fear regulation by increasing top-down control of the prefrontal cortex over the amygdala [47].”
From Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial (2014) · cites this paper as [45]
In the citing paper
“Human functional neuroimaging studies have shown that inhaling OT reduces BOLD (blood-oxygen-level dependent) activation in the amygdala when viewing or associating aversive social stimuli (Kirsch, 2005; Petrovic et al., 2008), during trust formation (Baumgartner et al., 2008), in response to pain (Singer et al., 2008), and in response to infant crying (Riem et al., 2011).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Kirsch, 2005
In the citing paper
“Some of these studies reveal differential activation in amygdala regions following OT administration while participating in social compared with non-social tasks (Kirsch et al., 2005;Domes et al., 2007), and others reveal enhanced Electroencephalography mu/alpha and beta suppression in response to biological vs non-biological motion following OT administration (Perry et al., 2010).”
From OT promotes closer interpersonal distance among highly empathic individuals (2015) · cites this paper as Kirsch et al., 2005
In the citing paper
“In addition, functional MRI (fMRI) studies have shown that OT administration dampened amygdala reactivity toward emotional stimuli in healthy males (Kirsch et al, 2005), males with generalized social anxiety disorder (GSAD; Labuschagne et al, 2010) and females with borderline personality disorder (BPD; Bertsch et al, 2013), although findings for females have been mixed (Domes et al, 2010).”
From Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients (2016) · cites this paper as Kirsch et al, 2005
In the citing paper
“to exert a more pronounced effect on amygdala deactivation while viewing faces vs. non-social scenes [16]”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [16]
In the citing paper
“possibly through dampening amygdala activation in response to fear-inducing stimuli [16], [17]”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [16]
In the citing paper
“its activity here tends to be reduced by OT administration upon exposure to threatening stimuli [18], [16], [17].”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [16]
In the citing paper
“Consistent with most previous studies, we found no effects of oxytocin on mood (Di Simplicio et al., 2009, Fischer-Shofty et al., 2010, Kirsch et al., 2005, Marsh et al., 2010).”
From Oxytocin decreases aversion to angry faces in an associative learning task (2010) · cites this paper as Kirsch et al., 2005
In the citing paper
“the anxiolytic action of OT via inhibiting amygdala responses to threatening stimuli (Kirsch et al., 2005; Petrovic et al., 2008)”
From Oxytocin facilitates approach behavior to positive social stimuli via decreasing anterior insula activity (2018) · cites this paper as Kirsch et al., 2005
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Measuring emotion: The self-assessment manikin and the semantic differential
Bradley, M. M., & Lang, P. J. (1994) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/0005-7916(94)90063-9 · Cited by 9,538
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
Whalen, P. J., Rauch, S. L., Etcoff, N. L., McInerney, S. C., Lee, M. B., & Jenike, M. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00411.1998 · Cited by 2,205
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091
Functional Connectivity: The Principal-Component Analysis of Large (PET) Data Sets
Friston, K. J., Frith, C., Liddle, P. F., & Frackowiak, R. S. J. (1993) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1993.4 · Cited by 1,997
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980
Self-citationPhelps, E. A., Delgado, M. R., Nearing, K. I., & LeDoux, J. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.042 · Cited by 1,753
Cognitive neuroscience of human social behaviour
Adolphs, R. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1056 · Cited by 1,657
LeDoux, J., Iwata, J., Cicchetti, P., & Reis, D. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02517.1988 · Cited by 1,580
Research works printed but not linked: 2
- 10.1038/nn849 · DOI · Paper page
- 1994, Diagnostica, 40, 320
Cited by
Sorted by citations
Items 101–200 of 348
Oxytocin receptor gene ( OXTR ) is related to psychological resources
Saphire-Bernstein, S., Way, B. M., Kim, H. S., Sherman, D. K., & Taylor, S. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113137108 · Cited by 262
Veenema, A. H., Bredewold, R., & Neumann, I. D. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.02.008 · Cited by 263
Post-learning intranasal oxytocin modulates human memory for facial identity
Savaskan, E., Ehrhardt, R., Schulz, A., Walter, M., & Schächinger, H. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.12.004 · Cited by 262
Centrally released oxytocin mediates mating-induced anxiolysis in male rats
Waldherr, M., & Neumann, I. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705860104 · Cited by 261
Chang, S. W. C., Barter, J. W., Ebitz, R. B., Watson, K. K., & Platt, M. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114621109 · Cited by 252
Oxytocin facilitates protective responses to aversive social stimuli in males
Striepens, N., Scheele, D., Kendrick, K. M., Becker, B., Schäfer, L., Schwalba, K., Reul, J., Maier, W., & Hurlemann, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208852109 · Cited by 242
Effects of intranasal oxytocin on the neural basis of face processing in autism spectrum disorder
Domes, G., Heinrichs, M., Kumbier, E., Grossmann, A., Hauenstein, K., & Herpertz, S. C. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.007 · Cited by 255
The cross-generation transmission of oxytocin in humans
Feldman, R., Gordon, I., & Zagoory-Sharon, O. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.06.005 · Cited by 256
Cannabinoid Modulation of Amygdala Reactivity to Social Signals of Threat in Humans
Phan, K. L., Angstadt, M., Golden, J., Onyewuenyi, I., Popovska, A., & de Wit, H. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5603-07.2008 · Cited by 251
Johnson, Z. V., & Young, L. J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.034 · Cited by 242
Singer, T., Snozzi, R., Bird, G., Petrovic, P., Silani, G., Heinrichs, M., & Dolan, R. J. (2008) · Emotion · doi:10.1037/a0014195 · Cited by 248
Mesotocin and nonapeptide receptors promote estrildid flocking behavior
Goodson, J. L., Schrock, S. E., Klatt, J. D., Kabelik, D., & Kingsbury, M. A. (2009) · Science · doi:10.1126/science.1174929 · Cited by 241
Auyeung, B., Lombardo, M. V., Heinrichs, M., Chakrabarti, B., Sule, A., Deakin, J. B., Bethlehem, R. A. I., Dickens, L., Mooney, N., Sipple, J. A. N., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.146 · Cited by 234
Dumont, G. J. H., Sweep, F. C. G. J., van der Steen, R., Hermsen, R., Donders, A. R. T., Touw, D. J., van Gerven, J. M. A., Buitelaar, J. K., & Verkes, R. J. (2009) · Social Neuroscience · doi:10.1080/17470910802649470 · Cited by 238
Guastella, A. J., & Hickie, I. B. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.028 · Cited by 223
Oxytocin and human social behavior.
Campbell, A. (2010) · Personality and Social Psychology Review · doi:10.1177/1088868310363594 · Cited by 232
The Role of Oxytocin in Human Affect: A Novel Hypothesis
Kemp, A. H., & Guastella, A. J. (2011) · Current Directions in Psychological Science · doi:10.1177/0963721411417547 · Cited by 228
Crawley, J. N., Chen, T., Puri, A., Washburn, R., Sullivan, T. L., Hill, J. M., Young, N. B., Nadler, J. J., Moy, S. S., Young, L. J., et al. (2007) · Neuropeptides · doi:10.1016/j.npep.2007.02.002 · Cited by 232
Kinetics and dose dependency of intranasal oxytocin effects on amygdala reactivity
Spengler, F. B., Schultz, J., Scheele, D., Essel, M., Maier, W., Heinrichs, M., & Hurlemann, R. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.04.015 · Cited by 229
Di Simplicio, M., Massey-Chase, R., Cowen, P., & Harmer, C. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881108095705 · Cited by 229
Groppe, S. E., Gossen, A., Rademacher, L., Hahn, A., Westphal, L., Gründer, G., & Spreckelmeyer, K. N. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.023 · Cited by 218
Puglia, M. H., Lillard, T. S., Morris, J. P., & Connelly, J. J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1422096112 · Cited by 216
Genetic origins of social networks in rhesus macaques
Brent, L. J. N., Heilbronner, S. R., Horvath, J. E., Gonzalez-Martinez, J., Ruiz-Lambides, A., Robinson, A. G., Skene, J. H. P., & Platt, M. L. (2013) · Scientific Reports · doi:10.1038/srep01042 · Cited by 220
Feduccia, A. A., & Mithoefer, M. C. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.03.003 · Cited by 217
Thompson, R. J., Parker, K. J., Hallmayer, J. F., Waugh, C. E., & Gotlib, I. H. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.07.003 · Cited by 211
Bradley, B., Westen, D., Mercer, K. B., Binder, E. B., Jovanovic, T., Crain, D., Wingo, A., & Heim, C. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000162 · Cited by 213
Oxytocin facilitates the extinction of conditioned fear in humans
Eckstein, M., Becker, B., Scheele, D., Scholz, C., Preckel, K., Schlaepfer, T. E., Grinevich, V., Kendrick, K. M., Maier, W., & Hurlemann, R. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.10.015 · Cited by 210
Bertsch, K., Gamer, M., Schmidt, B., Schmidinger, I., Walther, S., Kästel, T., Schnell, K., Büchel, C., Domes, G., & Herpertz, S. C. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13020263 · Cited by 214
Variation in the Oxytocin Receptor Gene Is Associated with Pair-Bonding and Social Behavior
Walum, H., Lichtenstein, P., Neiderhiser, J. M., Reiss, D., Ganiban, J. M., Spotts, E. L., Pedersen, N. L., Anckarsäter, H., Larsson, H., & Westberg, L. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.002 · Cited by 211
Dodhia, S., Hosanagar, A., Fitzgerald, D. A., Labuschagne, I., Wood, A. G., Nathan, P. J., & Phan, K. L. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.53 · Cited by 209
Behavioral effects of neuropeptides in rodent models of depression and anxiety
Rotzinger, S., Lovejoy, D. A., & Tan, L. A. (2010) · Peptides · doi:10.1016/j.peptides.2009.12.015 · Cited by 211
Neuroendocrinology of social information processing in rats and mice
Choleris, E., Clipperton-Allen, A. E., Phan, A., & Kavaliers, M. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.003 · Cited by 205
Epigenetic regulation of the oxytocin receptor gene: implications for behavioral neuroscience
Kumsta, R., Hummel, E., Chen, F. S., & Heinrichs, M. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00083 · Cited by 207
Effects of MDMA on sociability and neural response to social threat and social reward
Bedi, G., Phan, K. L., Angstadt, M., & de Wit, H. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1635-z · Cited by 206
Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex
Sripada, C. S., Phan, K. L., Labuschagne, I., Welsh, R., Nathan, P. J., & Wood, A. G. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000533 · Cited by 197
Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis
Elabd, C., Basillais, A., Beaupied, H., Breuil, V., Wagner, N., Scheideler, M., Zaragosi, L.-E., Massiéra, F., Lemichez, E., Trajanoski, Z., et al. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0127 · Cited by 202
Quirin, M., Kuhl, J., & Düsing, R. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.12.005 · Cited by 204
Oxytocin, the peptide that bonds the sexes also divides them
Gao, S., Becker, B., Luo, L., Geng, Y., Zhao, W., Yin, Y., Hu, J., Gao, Z., Gong, Q., Hurlemann, R., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602620113 · Cited by 186
Chronic and acute intranasal oxytocin produce divergent social effects in mice
Huang, H., Michetti, C., Busnelli, M., Managò, F., Sannino, S., Scheggia, D., Giancardo, L., Sona, D., Murino, V., Chini, B., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.310 · Cited by 199
Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications
Kohls, G., Chevallier, C., Troiani, V., & Schultz, R. T. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-10 · Cited by 197
Oxytocin increases amygdala reactivity to threatening scenes in females
Lischke, A., Gamer, M., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., Herpertz, S. C., & Domes, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.01.011 · Cited by 194
Neural circuits underlying crying and cry responding in mammals
Newman, J. D. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.02.011 · Cited by 198
Intranasal oxytocin blocks alcohol withdrawal in human subjects
Pedersen, C. A., Smedley, K. L., Leserman, J., Jarskog, L. F., Rau, S. W., Kampov‐Polevoi, A., Casey, R. L., Fender, T., & Garbutt, J. C. (2013) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01958.x · Cited by 196
Riem, M. M. E., van IJzendoorn, M. H., Tops, M., Boksem, M. A. S., Rombouts, S. A. R. B., & Bakermans-Kranenburg, M. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.313 · Cited by 191
Oxytocin receptor gene methylation: converging multilevel evidence for a role in social anxiety
Ziegler, C., Dannlowski, U., Bräuer, D., Stevens, S., Laeger, I., Wittmann, H., Kugel, H., Dobel, C., Hurlemann, R., Reif, A., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.2 · Cited by 193
Intranasal oxytocin attenuates the cortisol response to physical stress: a dose-response study
Cardoso, C., Ellenbogen, M. A., Orlando, M. A., Bacon, S. L., & Joober, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.07.013 · Cited by 187
Brain oxytocin in social fear conditioning and its extinction: involvement of the lateral septum
Zoicas, I., Slattery, D. A., & Neumann, I. D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.156 · Cited by 189
Oxytocin enhances inter-brain synchrony during social coordination in male adults
Mu, Y., Guo, C., & Han, S. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw106 · Cited by 177
The effect of intranasal administration of oxytocin on fear recognition
Fischer-Shofty, M., Shamay-Tsoory, S. G., Harari, H., & Levkovitz, Y. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.09.003 · Cited by 184
Watanabe, T., Abe, O., Kuwabara, H., Yahata, N., Takano, Y., Iwashiro, N., Natsubori, T., Aoki, Y., Takao, H., Kawakubo, Y., et al. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.3181 · Cited by 183
Switching brain serotonin with oxytocin
Mottolese, R., Redouté, J., Costes, N., Le Bars, D., & Sirigu, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319810111 · Cited by 179
Duque-Wilckens, N., Steinman, M. Q., Busnelli, M., Chini, B., Yokoyama, S., Pham, M., Laredo, S. A., Hao, R., Perkeybile, A. M., Minie, V. A., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.08.024 · Cited by 181
Oxytocin increases recognition of masked emotional faces
Schulze, L., Lischke, A., Greif, J., Herpertz, S. C., Heinrichs, M., & Domes, G. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.03.011 · Cited by 180
MacDonald, K., & Feifel, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00035 · Cited by 181
Wigton, R., Radua, J., Allen, P., Averbeck, B., Meyer-Lindenberg, A., McGuire, P., Shergill, S. S., & Fusar-Poli, P. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130289 · Cited by 179
Self-citationRosenfeld, A. J., Lieberman, J. A., & Jarskog, L. F. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq015 · Cited by 178
CSF and blood oxytocin concentration changes following intranasal delivery in macaque
Dal Monte, O., Noble, P. L., Turchi, J., Cummins, A., & Averbeck, B. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103677 · Cited by 177
Human neuroimaging of oxytocin and vasopressin in social cognition
Zink, C. F., & Meyer-Lindenberg, A. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.016 · Cited by 176
Self-citationMcGregor, I. S., Callaghan, P. D., & Hunt, G. E. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.132 · Cited by 171
Evolution and ontogeny of stress response to social challenges in the human child
FLINN, M. (2006) · Developmental Review · doi:10.1016/j.dr.2006.02.003 · Cited by 173
Hormonal mechanisms of cooperative behaviour
Soares, M. C., Bshary, R., Fusani, L., Goymann, W., Hau, M., Hirschenhauser, K., & Oliveira, R. F. (2010) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2010.0151 · Cited by 173
Intranasal administration of oxytocin: behavioral and clinical effects, a review
Veening, J. G., & Olivier, B. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.012 · Cited by 169
Schmahl, C., Herpertz, S. C., Bertsch, K., Ende, G., Flor, H., Kirsch, P., Lis, S., Meyer-Lindenberg, A., Rietschel, M., Schneider, M., et al. (2014) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/2051-6673-1-12 · Cited by 168
Self-citationSharing secrets: oxytocin and trust in schizophrenia
Kéri, S., Kiss, I., & Kelemen, O. (2009) · Social Neuroscience · doi:10.1080/17470910802319710 · Cited by 167
Association between the oxytocin receptor gene and amygdalar volume in healthy adults
Inoue, H., Yamasue, H., Tochigi, M., Abe, O., Liu, X., Kawamura, Y., Takei, K., Suga, M., Yamada, H., Rogers, M. A., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.019 · Cited by 164
Kamilar-Britt, P., & Bedi, G. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.016 · Cited by 163
Neumann, I. D. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.012 · Cited by 162
Wermter, A., Kamp‐Becker, I., Hesse, P., Schulte‐Körne, G., Strauch, K., & Remschmidt, H. (2010) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31032 · Cited by 163
A model of differential amygdala activation in psychopathy
Moul, C., Killcross, S., & Dadds, M. R. (2012) · Psychological Review · doi:10.1037/a0029342 · Cited by 159
Anxiolytic-like effect of oxytocin in the simulated public speaking test
de Oliveira, D. C., Zuardi, A. W., Graeff, F. G., Queiroz, R. H., & Crippa, J. A. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111400642 · Cited by 154
Domes, G., Kumbier, E., Heinrichs, M., & Herpertz, S. C. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.254 · Cited by 160
Neural mechanisms of social decision-making in the primate amygdala
Chang, S. W. C., Fagan, N. A., Toda, K., Utevsky, A. V., Pearson, J. M., & Platt, M. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514761112 · Cited by 157
Anagnostou, E., Soorya, L., Brian, J., Dupuis, A., Mankad, D., Smile, S., & Jacob, S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.049 · Cited by 155
Variant in oxytocin receptor gene is associated with amygdala volume
Furman, D. J., Chen, M. C., & Gotlib, I. H. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.12.004 · Cited by 151
Quintana, D. S., Alvares, G. A., Hickie, I. B., & Guastella, A. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.011 · Cited by 149
Yamasue, H., Yee, J. R., Hurlemann, R., Rilling, J. K., Chen, F. S., Meyer-Lindenberg, A., & Tost, H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3327-12.2012 · Cited by 149
Self-citationERK2 Contributes to the Control of Social Behaviors in Mice
Satoh, Y., Endo, S., Nakata, T., Kobayashi, Y., Yamada, K., Ikeda, T., Takeuchi, A., Hiramoto, T., Watanabe, Y., & Kazama, T. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2349-11.2011 · Cited by 145
Effects of intranasal oxytocin on 'compassion focused imagery'
Rockliff, H., Karl, A., McEwan, K., Gilbert, J., Matos, M., & Gilbert, P. (2011) · Emotion · doi:10.1037/a0023861 · Cited by 147
Beery, A. K., Lacey, E. A., & Francis, D. D. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21638 · Cited by 144
A heartfelt response: oxytocin effects on response to social stress in men and women
Kubzansky, L. D., Mendes, W. B., Appleton, A. A., Block, J., & Adler, G. K. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.02.010 · Cited by 142
Oxytocin׳s role in anxiety: A critical appraisal
MacDonald, K., & Feifel, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.025 · Cited by 139
Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome
Hall, S. S., Lightbody, A. A., McCarthy, B. E., Parker, K. J., & Reiss, A. L. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.020 · Cited by 143
Bredewold, R., & Veenema, A. H. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.02.011 · Cited by 144
MDMA enhances “mind reading” of positive emotions and impairs “mind reading” of negative emotions
Hysek, C. M., Domes, G., & Liechti, M. E. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2645-9 · Cited by 144
Intranasal oxytocin modulates EEG mu/alpha and beta rhythms during perception of biological motion
Perry, A., Bentin, S., Shalev, I., Israel, S., Uzefovsky, F., Bar-On, D., & Ebstein, R. P. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.04.011 · Cited by 143
Oxytocin Modulates Neural Reactivity to Children's Faces as a Function of Social Salience
Wittfoth-Schardt, D., Gründing, J., Wittfoth, M., Lanfermann, H., Heinrichs, M., Domes, G., Buchheim, A., Gündel, H., & Waller, C. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.47 · Cited by 139
Neural correlates of giving support to a loved one
Inagaki, T. K., & Eisenberger, N. I. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182359335 · Cited by 141
Social attachment and aversion in human moral cognition
Moll, J., & Schulkin, J. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.12.001 · Cited by 141
Intranasal Oxytocin Normalizes Amygdala Functional Connectivity in Posttraumatic Stress Disorder
Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.1 · Cited by 132
Acheson, D., Feifel, D., de Wilde, S., Mckinney, R., Lohr, J., & Risbrough, V. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3099-4 · Cited by 141
Interplay between Oxytocin and Sensory Systems in the Orchestration of Socio-Emotional Behaviors
Grinevich, V., & Stoop, R. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.016 · Cited by 139
Boccia, M. L., Goursaud, A.-P. S., Bachevalier, J., Anderson, K. D., & Pedersen, C. A. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.05.009 · Cited by 136
Extrahypothalamic oxytocin neurons drive stress-induced social vigilance and avoidance
Duque-Wilckens, N., Torres, L. Y., Yokoyama, S., Minie, V. A., Tran, A. M., Petkova, S. P., Hao, R., Ramos-Maciel, S., Rios, R. A., Jackson, K., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2011890117 · Cited by 139
A review of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy
Sessa, B., Higbed, L., & Nutt, D. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00138 · Cited by 141
“MDMA has been shown to facilitate the release of oxytocin, the hormone associated with early infantile bonding, which may increase levels of empathy and closeness (48–52) and dampen fear-related amygdala activity, causing a decrease in stress response and social anxiety (53, 54).”
BackgroundOxytocin and experimental therapeutics in autism spectrum disorders
BARTZ, J., & HOLLANDER, E. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00435-4 · Cited by 139
A registered replication study on oxytocin and trust
Declerck, C. H., Boone, C., Pauwels, L., Vogt, B., & Fehr, E. (2020) · Nature Human Behaviour · doi:10.1038/s41562-020-0878-x · Cited by 137
A psychobiological rationale for oxytocin in the treatment of posttraumatic stress disorder
Olff, M., Langeland, W., Witteveen, A., & Denys, D. (2010) · CNS Spectrums · doi:10.1017/s109285290000047x · Cited by 135
Oxytocin facilitates accurate perception of competition in men and kinship in women
Fischer-Shofty, M., Levkovitz, Y., & Shamay-Tsoory, S. G. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr100 · Cited by 132
Oxytocin blunts social vigilance in the rhesus macaque
Ebitz, R. B., Watson, K. K., & Platt, M. L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305230110 · Cited by 132
Gorka, S. M., Fitzgerald, D. A., Labuschagne, I., Hosanagar, A., Wood, A. G., Nathan, P. J., & Phan, K. L. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.168 · Cited by 131
Metadata
- Authors
- Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A.
- Affiliations
- Justus-Liebig-Universität Gießen (DE)
- National Institutes of Health (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-12-07
- Volume
- 25
- Issue
- 49
- Pages
- 11489-11493
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6725903
- OpenAlex
- W2121748618
- Cited by
- 1,639
- References
- 39
- Citations by year
- 2026: 31 · 2025: 32 · 2024: 45 · 2023: 43 · 2022: 44 · 2021: 79 · 2020: 97 · 2019: 82 · 2018: 85 · 2017: 103 · 2016: 99 · 2015: 107 · 2014: 119 · 2013: 122 · 2012: 119
- FWCI
- 67.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- KOPS (University of Konstanz) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- oxytocin, amygdala, fear conditioning, social cognition, neural circuits, intranasal administration, trust, anxiety, social anxiety disorder, autism spectrum disorder, fear extinction
- MeSH terms
- Adolescent, Adult, Cognition, Double-Blind Method, Fear, Humans, Magnetic Resonance Imaging, Male, Nerve Net, Oxytocin, Photic Stimulation, Psychomotor Performance, Social Behavior
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
