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H OW H OST-M ICROBIAL I NTERACTIONS S HAPE THE N UTRIENT E NVIRONMENT OF THE M AMMALIAN I NTESTINE
Abstract
▪ Abstract Humans and other mammals are colonized by a vast, complex, and dynamic consortium of microorganisms. One evolutionary driving force for maintaining this metabolically active microbial society is to salvage energy from nutrients, particularly carbohydrates, that are otherwise nondigestible by the host. Much of our understanding of the molecular mechanisms by which members of the intestinal microbiota degrade complex polysaccharides comes from studies of Bacteroides thetaiotaomicron, a prominent and genetically manipulatable component of the normal human and mouse gut. Colonization of germ-free mice with B. thetaiotaomicron has shown how this anaerobe modifies many aspects of intestinal cellular differentiation/gene expression to benefit both host and microbe. These and other studies underscore the importance of understanding precisely how nutrient metabolism serves to establish and sustain symbiotic relationships between mammals and their bacterial partners.
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Pereira-Fantini, P. M., Byars, S. G., Pitt, J., Lapthorne, S., Fouhy, F., Cotter, P. D., & Bines, J. E. (2017) · Scientific Reports · doi:10.1038/srep43326 · Cited by 22
Hsu, T.-H., Chiu, C.-C., Wang, Y.-C., Chen, T.-H., Chen, Y.-H., Lee, Y.-P., Hung, S.-W., Wu, C.-P., & Chuang, H.-L. (2018) · Nutrients · doi:10.3390/nu10111740 · Cited by 20
Metadata
- Authors
- Hooper, L. V., Midtvedt, T., & Gordon, J. I.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2002-07
- Volume
- 22
- Issue
- 1
- Pages
- 283-307
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2120459847
- Cited by
- 1,621
- References
- 6
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.