The DOI matches its Crossref record; 232 of the 232 references it cites were found in a registry or an index; none of the 246 sources its claims cite is checked for support yet.
Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions†
Open accessAbstract
The survey focuses on recent aspects of photochemical reactions to cellular DNA that are implicated through the predominant formation of mostly bipyrimidine photoproducts in deleterious effects of human exposure to sunlight. Recent developments in analytical methods have allowed accurate and quantitative measurements of the main DNA photoproducts in cells and human skin. Highly mutagenic CC and CT bipyrimidine photoproducts, including cyclobutane pyrimidine dimers and pyrimidine (6‐4) pyrimidone photoproducts (6‐4PPs) are generated in low yields with respect to TT and TC photoproducts. Another striking finding deals with the formation of Dewar valence isomers, the third class of bipyrimidine photoproducts that is accounted for by UVA‐mediated isomerization of initially UVB generated 6‐4PPs. Cyclobutadithymine (T<>T) has been unambiguously shown to be involved in the genotoxicity of UVA radiation. Thus, T<>T is formed in UVA‐irradiated cellular DNA according to a direct excitation mechanism with a higher efficiency than oxidatively generated DNA damage that arises mostly through the Type II photosensitization mechanism. C<>C and C<>T are repaired at rates intermediate between those of T<>T and 6‐4TT. Evidence has been also provided for the occurrence of photosensitized reactions mediated by exogenous agents that act either in an independent way or through photodynamic effects.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
0 of 246 cited sources checked · 0 supported · 0 flagged
None of the sources cited for this claim have been checked yet.
In the paper
“It is now well documented that DNA is the main critical cellular macromolecule for determining the carcinogenic effects of solar radiation (7)(8)(9).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > INTRODUCTION
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIn the paper
“Overall cumulated dose is a good predictor of induction of squamous cell carcinoma and lip cancers (1).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > INTRODUCTION
What the sources say
- Not checked yetcites [1] source
Strength:boosted· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“In contrast, basal cell carcinoma and malignant melanoma incidence appears to be mostly related to intermittent exposure to solar light during childhood and adolescence (1), although the situation for melanoma appears to be more complex (2).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > INTRODUCTION
Strength:hedged· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIn the paper
“Occupational and recreational exposure of humans to UVB and UVA radiations present in sunlight represents a major environmental risk factor for the development of skin cancers.”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > INTRODUCTION
What the sources say
- Not checked yetcites [1] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“Another early relevant finding dealt with the isolation of a second thymine dimeric photoproduct in UVC-irradiated thymidylyl-(3¢-5¢)-thymidine (TpT) (25) that has been identified as a pyrimidine (6-4) pyrimidone photoproduct (6-4PP) (26,27).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > INTRODUCTION
What the sources say
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“with the observation of UVB-induced C fi T transition and CC fi TT mutations at bipyrimidine sites in p53 genes of skin tumors (8,15).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > INTRODUCTION
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIn the paper
“T< >T has been shown later to be the predominant DNA photoproduct induced in cellular DNA upon UVB and solar irradiation (22).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > INTRODUCTION
What the sources say
- Not checked yetcites [22] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIn the paper
“DNA damage induced by UVB radiation is dominated by bipyrimidine photoproducts (22).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > UVB-induced CPDs and 6-4PPs
What the sources say
- Not checked yetcites [22] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIn the paper
“The formation of oxidation products, more specifically 8-oxodGuo, is also induced in cellular DNA upon exposure to UVB radiation however in a low yield that is 2-3 orders of magnitude lower than that of either CPDs or 6-4PPs (32).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > UVB-induced CPDs and 6-4PPs
What the sources say
- Not checked yetcites [32] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesThe paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“The formation of these photoproducts results from the presence of a pyrimidone moiety in 6-4PPs that may absorb photons with a maximal efficiency around 320 nm.”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Main properties of the photoproducts.
Strength:hedged· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes
- It may state two separate claims as one. 43
- The quote only partly states this claim. 1
- Probably not a substantial claim. 7
None of the sources cited for this claim have been checked yet.
In the paper
“Other earlier striking findings concerning UVAinduced DNA photoproducts dealt with the identification of cyclobutane pyrimidine dimers (CPDs) (29,30) and oxidatively generated damage (30)(31)(32), including 8-oxo-7,8-dihydro-2¢deoxyguanosine (8-oxodGuo) (31) in cellular DNA.”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > INTRODUCTION
What the sources say
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Another indirect evidence for the implication of photoinduced damage to DNA in carcinogenicity is provided by the high incidence of skin tumors in most of the complementation groups A-G of xeroderma pigmentosum patients (17,18) who suffer from deficiencies in nucleotide excision repair (19).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > INTRODUCTION
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Other photoproducts such as cytosine hydrates (41,42) or adenine-containing dimers (43,44) have been isolated in model systems but their yields are 2 orders of magnitude lower than that of bipyrimidine photoproducts in double-stranded (ds) DNA.”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > UVB-induced CPDs and 6-4PPs
What the sources say
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“The half reaction time is in the range of a few hours for isolated photoproducts and slightly less in ds DNA.”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Main properties of the photoproducts.
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“This reaction in DNA is mediated via singlet excited state as shown by the complete absence of formation of 6-4PPs upon photosensitized triplet state energy transfer.”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > UVB-induced CPDs and 6-4PPs
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“and by the fact that 6-4PPs, although highly mutagenic, are efficiently removed by repair systems.”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > UVB-induced CPDs and 6-4PPs
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Surprisingly, it was also reported that the 6-4TT lacking the internal phosphodiester bond is not able to undergo photorearrangement into the related Dewar valence isomer upon white light irradiation, suggesting that the DNA backbone could favor the photoisomerization of 6-4PPs.”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Main properties of the photoproducts.
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“In contrast, CT and CC sites are much less susceptible to UVB-mediated reactions that lead mostly to the formation of CPDs.”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Distribution of photoproducts in DNA.
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“The yield of bipyrimidine photoproducts is much lower in skin than in cells, although the distribution of photoproducts is similar (61).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Distribution of photoproducts in DNA.
What the sources say
- Not checked yetcites [61] source
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In contrast, the frequency of 6-4PPs decreases and DEWs can be detected in significant amounts while they are not present when cells are only exposed to UVB (Fig. 2).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Distribution of photoproducts in DNA.
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“The TC sequences also show fair reactivity with both T< >C and 6-4TC being produced in similar yields.”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Distribution of photoproducts in DNA.
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Sequencing techniques showed that methylated CpG sites were more prone to photoproduct formation (72) and were mutational hotspots, likely as the result of deamination (73).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Distribution of photoproducts in DNA.
What the sources say
- Not checked yetcites [72]
- Not checked yetcites [73] source
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Evidence has also been provided for the enhanced efficiency of photoreactions in telomeres (70) with the possible formation of interstrand lesions in the quadruplex region (71).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Distribution of photoproducts in DNA.
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“The latter intermediate quantitatively rearranges within ds DNA into 8-hydroxyperoxyguanine (39,99) that is further reduced into 8-oxoGua (Fig. 5), the exclusive 1 O 2 oxidation product (39,100,101).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > The diversity of DNA photo-oxidation mechanisms
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“However, it is now established that 1 O 2 has no ability to cleave the DNA backbone and that earlier observations concerning formation of DNA nicks would be explained by the occurrence of secondary oxidation of 8-oxoGua that is about 100-fold more reactive than guanine toward 1 O 2 .”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > The diversity of DNA photo-oxidation mechanisms
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“It may be added, although being a much lower process than in the UVC and UVB ranges, that absorption of UVA photons by DNA is a well-documented fact (94) that was recently shown to be driven by the stacking of bases in the double helix (95,96).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > UVA-induced CPDs
What the sources say
Strength:boosted· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Indeed, neither UVB nor UVA photons provide enough energy to directly enable one-electron oxidation of DNA bases, although the double-stranded structure lowers the ionization potentials of the nucleobases.”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > UVA-INDUCED OXIDATION REACTIONS (ENDOGENOUS PHOTOSENSITIZERS)
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“The singlet excited states arising from initial UVA photon absorption that are characterized by a marked charge transfer state appear to be quite different from those induced by UVB irradiation (95).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > UVA-induced CPDs
What the sources say
- Not checked yetcites [95] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“While bipyrimidine photoproducts are produced by direct excitation of the DNA bases, the formation of oxidatively generated lesions including 8-oxoGua obeys indirect photosensitized mechanisms (Fig. 4).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > UVA-INDUCED OXIDATION REACTIONS (ENDOGENOUS PHOTOSENSITIZERS)
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“The unique target among DNA components is guanine that is converted into a 4,8-endoperoxide through 1 O 2mediated-Diels Alder [4+2] photocycloaddition reaction.”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > The diversity of DNA photo-oxidation mechanisms
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“A second possible DNA photosensitization pathway involves one-electron oxidation by excited chromophores, also known as the Type I photosensitization mechanism.The efficiency of this reaction is driven by the oxidation potential of the photosensitizers that preferentially act on guanine.”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > The diversity of DNA photo-oxidation mechanisms
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“In the case of UVA, • OH results from the fate of far less reactive O 2”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Hydroxyl radical-mediated DNA damage.
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesThe quote only partly states this claim.
In the paper
“Interestingly, it was shown that UVA leads to the release of iron from ferritin, therefore potentiating emergence of Fenton reactions (107).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > •)
What the sources say
- Not checked yetcites [107] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“The second most frequent UVA-induced DNA oxidatively generated lesions are strand breaks that are formed in an approximately three-time lower yield than oxidized purines.”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > UVA-mediated oxidatively generated DNA damage in cells
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Subsequently, O 2 •) can be converted by spontaneous or more likely by superoxide dismutase-driven dismutation into hydrogen peroxide (H 2 O 2 ).The latter species is the direct precursor of • OH upon reaction with reduced transition metal ions such as Fe 2+ or Cu + in a chemical process known as the Fenton reaction.”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > •)
Strength:hedged· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“Upon loss of an electron, guanine is converted into a radical cation (Gua •+ ) that may undergo hydration with subsequent conversion to reducing the 8-hydroxy-7,8-dihydroguanyl radical.The latter transient radical is subsequently converted to 8-oxoGua and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) by competitive one-electron oxidation and one-electron reduction, respectively.”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > The diversity of DNA photo-oxidation mechanisms
What the sources say
- Not checked yetcites [103] source
Strength:hedged· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“As already mentioned, DNA only absorbs slightly in the lower part of the UVA range of solar radiation up to 340 nm, leading mostly to the formation of cis-syn T<>T through delocalization of excited state transients on several nucleobases (95,96).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > SENSITIZED REACTIONS TO UVA RADIATION BY EXOGENOUS COMPOUNDS
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“Therefore, an increase in laser pulse intensity is accompanied with a decrease in the quantum yield of CPDs and 6-4PPs.In contrast, the level of 8-oxoGua, the main DNA oxidation product, and of other oxidized bases including 8-oxoAde, ThyGl, 5-HmUra and 5-FoUra increases (128).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > IONIZATION OF NUCLEOBASES BY HIGH-INTENSITY UVC LASER PULSES
What the sources say
- Not checked yetcites [128] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Exposure of cells to low linear energy transfer ionizing radiation like X-or c-rays that act mostly through the production of • OH gives rise to strand breaks and oxidized bases in a 1.3:1 ratio while the formation yields of purine and pyrimidine oxidation products are similar.”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > UVA-mediated oxidatively generated DNA damage in cells
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Furocoumarins including bifunctional 8-methoxypsoralen (8-MOP) and 5-methoxypsoralen (5-MOP) are still used in the so-called ''psoralen plus UVA (PUVA)'' therapy of rather frequent hyperproliferative skin diseases, including psoriasis and vitiligo (153-155).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Photocyloaddition reactions of psoralen derivatives
What the sources say
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Major mechanistic insights into the mechanisms of [2+2] photocycloaddition of furocoumarin derivatives to the 5,6-double bond of thymidine, the major target of these oxygen-independent photoreactions, have been gained from extensive model studies (35,(161)(162)(163).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Photocyloaddition reactions of psoralen derivatives
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Other applications of psoralen derivatives deal with the photopheresis of cutaneous T-cell lymphoma (156-158) and the photoinactivation of pathogens in plasma and platelet components (159,160).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Photocyloaddition reactions of psoralen derivatives
What the sources say
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“The repair rate of ICLs that is rather slow, requiring at least 24 h to be completed, was found to decrease with an increase in the concentration of 8-MOP (164).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Photocyloaddition reactions of psoralen derivatives
What the sources say
- Not checked yetcites [164] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“The fast disappearance in the postincubation repair period of the two diastereomers with a half-life of about 90 min would suggest implication of the base excision repair pathway for their enzymatic removal.”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Photocyloaddition reactions of psoralen derivatives
What the sources say
- Not checked yetcites [167] source
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“Among fluoroquinolones (for recent reviews, see Lhiaubet ), lomefloxacin and, to a lesser extent, enoxacin act as predominant Type I photosensitizers whereas ofloxacin and norfloxacin react with DNA mainly through 1 O 2 oxidation (93).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Oxidation reactions mediated by photosensitizers
What the sources say
- Not checked yetcites [93]
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“It was subsequently confirmed that ofloxacin oxidized predominantly DNA mostly through the Type II mechanism (177) as also shown for norfloxacin (178).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Oxidation reactions mediated by photosensitizers
Strength:boosted· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“UVA-excited TiO 2 has been shown to generate 1 O 2 (189), O 2) and also highly reactive • OH either through reduction of surface hydroxyl group by valence bond holes (190) or by Fenton type reactions (191).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Oxidation reactions mediated by photosensitizers
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“• OH has been also proposed to explain the increased level of oxidatively generated damage to DNA measured as Fpgsensitive sites in the DNA of UVA-irradiated goldfish skin GFSk-S1 cells pretreated with TiO 2 nanoparticles (202).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Oxidation reactions mediated by photosensitizers
What the sources say
- Not checked yetcites [202] source
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Thiopurines including azathioprine, 6-mercaptopurine and 6thioguanine (6-TG) are widely used in cancer therapy, for the treatment of inflammatory disorders and as immunosuppressants (204,205).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Oxidatively generated and complex DNA lesions induced by UVA activation of thiopurines
What the sources say
- Not checked yetcites [204]
- Not checked yetcites [205] source
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Cationic 5,10,15,20-tetrakis (N-methyl-4-pyridyl)-21H,23H-porphyrin that is mostly localized in the nuclei of human leukemia HL-60 cells as inferred from confocal fluorescence microscopy is able to UVA sensitize the formation of 8-oxoGua through predominant Type II photosensitization mechanisms (186).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Oxidation reactions mediated by photosensitizers
What the sources say
- Not checked yetcites [186] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“In contrast, protoporphyrin IX derived from 5-aminolevulinic acid and whose preferential localization was observed in the cytoplasm was found to generate only small amounts of 8-oxoGua upon UVA illumination (186).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Oxidation reactions mediated by photosensitizers
What the sources say
- Not checked yetcites [186] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Photoexcited TiO 2 exhibits strong bactericidal activity (191)(192)(193)(194) and genotoxicity (195)(196)(197)(198) on various cells as mostly the result of oxidative stress.”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Oxidation reactions mediated by photosensitizers
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Nanoparticles (ca 100 nm or smaller) of titanium dioxide (TiO 2 ), a white pigment, are widely used for various industrial purposes, including the design of sun blockers and other cosmetic products (187,188).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Oxidation reactions mediated by photosensitizers
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“This is explained by the metabolization and incorporation of thiopurines into DNA as 6-thio-2¢-deoxyguanosine, an efficient endogenous Type I and Type II photosensitizer absorbing in the UVA range with a maximum at 342 nm (209).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Oxidatively generated and complex DNA lesions induced by UVA activation of thiopurines
What the sources say
- Not checked yetcites [209] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“Some of the proposed structures of DPCs formed between oligonucleotides and short peptides involve covalent binding of highly reactive 6-TG with cysteine residues through the generation of a disulfide (214).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Oxidatively generated and complex DNA lesions induced by UVA activation of thiopurines
What the sources say
- Not checked yetcites [214] source
Strength:hedged· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Free peptide amino groups were also suggested to participate in the 6-TG-mediated formation of DPCs.”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Oxidatively generated and complex DNA lesions induced by UVA activation of thiopurines
What the sources say
- Not checked yetcites [214] source
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“4-Thiothymine (S4Thy), a thymine analog absorbing in the UVA range with a maximum centered around 340 nm is able to efficiently incorporate into the DNA of dividing cells (225,226).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Oxidatively generated and complex DNA lesions induced by UVA activation of thiopurines
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“However, the DPCs that were generated in cellular DNA were resistant to reduction treatment in contrast to those formed in model studies (214), ruling out the possible structures that were discussed above.”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Oxidatively generated and complex DNA lesions induced by UVA activation of thiopurines
What the sources say
- Not checked yetcites [214] source
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“In addition to water that was found initially to efficiently react with Gua •+ (218), several amino acids bearing a nucleophilic group, including lysine, arginine and serine were shown to covalent bind to the C8 of guanine (111,216).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Oxidatively generated and complex DNA lesions induced by UVA activation of thiopurines
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“This was found to lead to the generation of ROS upon UVA irradiation with subsequent formation of DNA oxidation products that is accompanied by a loss of mitochondrial function (224).”
§ Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions † > Oxidatively generated and complex DNA lesions induced by UVA activation of thiopurines
What the sources say
- Not checked yetcites [224] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
The paper relies on this without support.
Mechanisms of DNA photoproduct formation derived from model studies apply to cellular DNA.
“Major mechanistic insights into the mechanisms of [2+2] photocycloaddition of furocoumarin derivatives to the 5,6-double bond of thymidine, the major target of these oxygen-independent photoreactions, have been gained from extensive model studies (35,(161)(162)(163).”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“6-4PPs are formed by one covalent bond between the 5'-end C6 and the 3'-end C4 carbon atoms of adjacent pyrimidines via charge-transfer states, and oxetane and azetidine rearrangements (unstable intermediates) occur when the 3'-end is T or C, respectively [31,32].”
From Sunlight damage to cellular DNA: focus on oxidatively generated lesions (2017) · cites this paper as [32]
In the citing paper
“solar UV is a potent environmental human carcinogen (10–12).”
From Hypochlorous Acid: From Innate Immune Factor and Environmental Toxicant to Chemopreventive Agent Targeting Solar UV-Induced Skin Cancer (2022) · cites this paper as [12]
Citations
Cites
Steenken, S., & Jovanovic, S. V. (1997) · Journal of the American Chemical Society · doi:10.1021/ja962255b · Cited by 1,450
Photochemotherapy of Psoriasis with Oral Methoxsalen and Longwave Ultraviolet Light
Parrish, J. A., Fitzpatrick, T. B., Tanenbaum, L., & Pathak, M. A. (1974) · New England Journal of Medicine · doi:10.1056/nejm197412052912301 · Cited by 1,376
Molecular Mechanisms of Ultraviolet Radiation‐Induced DNA Damage and Repair
Rastogi, R. P., Richa, Kumar, A., Tyagi, M. B., & Sinha, R. P. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/592980 · Cited by 1,329
Definition of type I and type II photosensitized oxidation
Foote, C. S. (1991) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1991.tb02071.x · Cited by 1,248
Gurr, J.-R., Wang, A. S. S., Chen, C.-H., & Jan, K.-Y. (2005) · Toxicology · doi:10.1016/j.tox.2005.05.007 · Cited by 1,022
Pogozelski, W. K., & Tullius, T. D. (1998) · Chemical Reviews · doi:10.1021/cr960437i · Cited by 1,018
THE DISAPPEARANCE OF THYMINE DIMERS FROM DNA: AN ERROR-CORRECTING MECHANISM
Setlow, R. B., & Carrier, W. L. (1964) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.51.2.226 · Cited by 984
Direct and indirect effects of UV radiation on DNA and its components
Ravanat, J.-L., Douki, T., & Cadet, J. (2001) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(01)00206-8 · Cited by 980
Self-citationUltraviolet radiation-mediated damage to cellular DNA
Cadet, J., Sage, E., & Douki, T. (2005) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2004.09.012 · Cited by 932
Self-citationA review of human carcinogens--part D: radiation
El Ghissassi, F., Baan, R., Straif, K., Grosse, Y., Secretan, B., Bouvard, V., Benbrahim-Tallaa, L., Guha, N., Freeman, C., Galichet, L., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70213-x · Cited by 900
Mutations induced by ultraviolet light
Pfeifer, G. P., You, Y., & Nia, A. B. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.06.057 · Cited by 798
Mechanisms for DNA Charge Transport
Genereux, J. C., & Barton, J. K. (2010) · Chemical Reviews · doi:10.1021/cr900228f · Cited by 787
Long-Range Charge Transfer in DNA: Transient Structural Distortions Control the Distance Dependence
Schuster, G. B. (2000) · Accounts of Chemical Research · doi:10.1021/ar980059z · Cited by 778
Cimino, G. D., Gamper, H., Isaacs, S. T., & Hearst, J. E. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.54.070185.005443 · Cited by 746
Hydroxyl radicals and DNA base damage
Cadet, J., Delatour, T., Douki, T., Gasparutto, D., Pouget, J., Ravanat, J., & Sauvaigo, S. (1999) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(99)00004-4 · Cited by 725
Self-citationInorganic and organic UV filters: Their role and efficacy in sunscreens and suncare products
Serpone, N., Dondi, D., & Albini, A. (2007) · Inorganica Chimica Acta · doi:10.1016/j.ica.2005.12.057 · Cited by 711
Mouret, S., Baudouin, C., Charveron, M., Favier, A., Cadet, J., & Douki, T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604213103 · Cited by 684
Self-citationWavelength dependence of oxidative DNA damage induced by UV and visible light
Kielbassa, C. (1997) · Carcinogenesis · doi:10.1093/carcin/18.4.811 · Cited by 616
Cadet, J., Douki, T., & Ravanat, J.-L. (2008) · Accounts of Chemical Research · doi:10.1021/ar700245e · Cited by 555
Self-citationThymine Dimerization in DNA Is an Ultrafast Photoreaction
Schreier, W. J., Schrader, T. E., Koller, F. O., Gilch, P., Crespo-Hernández, C. E., Swaminathan, V. N., Carell, T., Zinth, W., & Kohler, B. (2007) · Science · doi:10.1126/science.1135428 · Cited by 550
Shining a light on xeroderma pigmentosum
DiGiovanna, J. J., & Kraemer, K. H. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.426 · Cited by 547
The Mechanisms of UV Mutagenesis
Ikehata, H., & Ono, T. (2011) · Journal of Radiation Research · doi:10.1269/jrr.10175 · Cited by 542
Chemical oxidation and DNA damage catalysed by inorganic sunscreen ingredients
Dunford, R., Salinaro, A., Cai, L., Serpone, N., Horikoshi, S., Hidaka, H., & Knowland, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01356-2 · Cited by 540
Encyclopedia of radicals in chemistry, biology and materials
(2012) · Choice Reviews Online · doi:10.5860/choice.49-6017 · Cited by 532
Karran, P., & Attard, N. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2292 · Cited by 477
UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer
Pfeifer, G. P., & Besaratinia, A. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05144j · Cited by 473
Isolation and identification of the irradiation product of thymine
Beukers, R., & Berends, W. (1960) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(60)90063-9 · Cited by 471
Douki, T., Reynaud-Angelin, A., Cadet, J., & Sage, E. (2003) · Biochemistry · doi:10.1021/bi034593c · Cited by 452
Self-citationReeves, J. F., Davies, S. J., Dodd, N. J. F., & Jha, A. N. (2008) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2007.12.010 · Cited by 441
Wondrak, G. T., Jacobson, M. K., & Jacobson, E. L. (2006) · Photochemical & Photobiological Sciences · doi:10.1039/b504573h · Cited by 411
UV-induced DNA damage and melanin content in human skin differing in racial/ethnic origin
Tadokoro, T., Kobayashi, N., Zmudzka, B. Z., Ito, S., Wakamatsu, K., Yamaguchi, Y., Korossy, K. S., Miller, S. A., Beer, J. Z., & Hearing, V. J. (2003) · The FASEB Journal · doi:10.1096/fj.02-0865fje · Cited by 378
Induction of oxidative DNA base damage in human skin cells by UV and near visible radiation
Kvam, E. (1997) · Carcinogenesis · doi:10.1093/carcin/18.12.2379 · Cited by 344
Lehmann, A. R., McGibbon, D., & Stefanini, M. (2011) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-6-70 · Cited by 343
Oxidation of DNA: Damage to Nucleobases
Kanvah, S., Joseph, J., Schuster, G. B., Barnett, R. N., Cleveland, C. L., & Landman, U. (2010) · Accounts of Chemical Research · doi:10.1021/ar900175a · Cited by 338
Douki, T., & Cadet, J. (2001) · Biochemistry · doi:10.1021/bi0022543 · Cited by 337
Self-citationMelanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment
Noonan, F. P., Zaidi, M. R., Wolnicka-Glubisz, A., Anver, M. R., Bahn, J., Wielgus, A., Cadet, J., Douki, T., Mouret, S., Tucker, M. A., et al. (2012) · Nature Communications · doi:10.1038/ncomms1893 · Cited by 331
Self-citationSinglet Oxygen Induces Oxidation of Cellular DNA
Ravanat, J., Mascio, P. D., Martinez, G. R., de Medeiros, M. H. G., & Cadet, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006681200 · Cited by 327
Self-citationEVIDENCE THAT ULTRAVIOLET-INDUCED THYMINE DIMERS IN DNA CAUSE BIOLOGICAL DAMAGE
Setlow, R. B., & Setlow, J. K. (1962) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.48.7.1250 · Cited by 319
You, Y.-H., Lee, D.-H., Yoon, J.-H., Nakajima, S., Yasui, A., & Pfeifer, G. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107696200 · Cited by 314
Freeman, S. E., Hacham, H., Gange, R. W., Maytum, D. J., Sutherland, J. C., & Sutherland, B. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.14.5605 · Cited by 311
Oxidative Damage to Nucleic Acids Photosensitized by Titanium Dioxide
Wamer, W. G., Yin, J., & Wei, R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00068-3 · Cited by 310
TiO2 Nanoparticles Are Phototoxic to Marine Phytoplankton
Miller, R. J., Bennett, S. W., Keller, A. A., Pease, S., & Lenihan, H. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030321 · Cited by 304
Kasai, H., Yamaizumi, Z., Berger, M., & Cadet, J. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00050a078 · Cited by 300
Self-citationIn situ analysis of repair processes for oxidative DNA damage in mammalian cells
Lan, L., Nakajima, S., Oohata, Y., Takao, M., Okano, S., Masutani, M., Wilson, S. H., & Yasui, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406048101 · Cited by 299
Unraveling the Molecular Pathway from Sunlight to Skin Cancer
Taylor, J. (1994) · Accounts of Chemical Research · doi:10.1021/ar00039a003 · Cited by 283
Pouget, J.-P., Douki, T., Richard, M.-J., & Cadet, J. (2000) · Chemical Research in Toxicology · doi:10.1021/tx000020e · Cited by 274
Self-citationBenzophenone Photosensitized DNA Damage
Cuquerella, M. C., Lhiaubet‐Vallet, V., Cadet, J., & Miranda, M. A. (2012) · Accounts of Chemical Research · doi:10.1021/ar300054e · Cited by 265
Self-citationMechanisms of Skin Tanning in Different Racial/Ethnic Groups in Response to Ultraviolet Radiation
Tadokoro, T., Yamaguchi, Y., Batzer, J., Coelho, S. G., Zmudzka, B. Z., Miller, S. A., Wolber, R., Beer, J. Z., & Hearing, V. J. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23760.x · Cited by 257
Distribution and Repair of Bipyrimidine Photoproducts in Solar UV-irradiated Mammalian Cells
Perdiz, D., Gróf, P., Mezzina, M., Nikaido, O., Moustacchi, E., & Sage, E. (2000) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61437-7 · Cited by 248
Kuluncsics, Z., Perdiz, D., Brulay, E., Muel, B., & Sage, E. (1999) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(99)00034-2 · Cited by 239
Sunlight induces pyrimidine dimers preferentially at 5-methylcytosine bases.
Tommasi, S., Denissenko, M. F., & Pfeifer, G. P. (1997) · PubMed · Cited by 236
Oxidatively generated complex DNA damage: Tandem and clustered lesions
Cadet, J., Ravanat, J.-L., TavernaPorro, M., Menoni, H., & Angelov, D. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.04.005 · Cited by 233
Self-citationRochette, P. J. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg402 · Cited by 231
Powerful Skin Cancer Protection by a CPD-Photolyase Transgene
Jans, J., Schul, W., Sert, Y.-G., Rijksen, Y., Rebel, H., Eker, A. P. M., Nakajima, S., van Steeg, H., de Gruijl, F. R., Yasui, A., et al. (2005) · Current Biology · doi:10.1016/j.cub.2005.01.001 · Cited by 227
Absorption spectrum of DNA for wavelengths greater than 300 nm
Sutherland, J. C., & Griffin, K. P. (1981) · Radiation Research · doi:10.2307/3575456 · Cited by 214
Sensitized formation of oxidatively generated damage to cellular DNA by UVA radiation
Cadet, J., Douki, T., Ravanat, J.-L., & Di Mascio, P. (2009) · Photochemical & Photobiological Sciences · doi:10.1039/b905343n · Cited by 213
Self-citationCadet, J., Anselmino, C., Douki, T., & Voituriez, L. (1992) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/1011-1344(92)85135-h · Cited by 211
Self-citationINDUCTION OF PYRIMIDINE DIMERS IN BACTERIAL DNA BY 365 nm RADIATION*
TYRRELL, R. M. (1973) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1973.tb06334.x · Cited by 203
The photogenotoxicity of titanium dioxide particles
Nakagawa, Y., Wakuri, S., Sakamoto, K., & Tanaka, N. (1997) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(97)00126-5 · Cited by 200
Short- and Long-Wave UV Light (UVB and UVA) Induce Similar Mutations in Human Skin Cells
Kappes, U. P., Luo, D., Potter, M., Schulmeister, K., & Rünger, T. M. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700093 · Cited by 200
Favre, A., Saintomé, C., Fourrey, J.-L., Clivio, P., & Laugâa, P. (1998) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(97)00116-4 · Cited by 191
The ultraviolet photochemistry of thymidylyl-(3′→5′)-thymidine
Johns, H. E., Pearson, M. L., LeBlanc, J. C., & Helleiner, C. W. (1964) · Journal of Molecular Biology · doi:10.1016/s0022-2836(64)80223-0 · Cited by 191
Strahlenchemische Ver�nderung der Bakterien-Desoxyribonucleins�ure in vivo
Wacker, A., Dellweg, H., & Weinblum, D. (1960) · Die Naturwissenschaften · doi:10.1007/bf00638304 · Cited by 183
Thiopurines, DNA damage, DNA repair and therapy-related cancer
Karran, P. (2006) · British Medical Bulletin · doi:10.1093/bmb/ldl020 · Cited by 182
Pourzand, C., Watkin, R. D., Brown, J. E., & Tyrrell, R. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6751 · Cited by 176
Singlet Oxygen Oxidation of Isolated and Cellular DNA: Product Formation and Mechanistic Insights
Cadet, J., Ravanat, J., Martinez, G. R., Medeiros, M. H. G., & Mascio, P. D. (2006) · Photochemistry and Photobiology · doi:10.1562/2006-06-09-ir-914 · Cited by 176
Self-citationDNA, light, and Dewar pyrimidinones: the structure and biological significance to TpT3
Taylor, J. S., & Cohrs, M. P. (1987) · Journal of the American Chemical Society · doi:10.1021/ja00243a052 · Cited by 174
Lin, L., Hanson, C. V., Alter, H. J., Jauvin, V., Bernard, K. A., Murthy, K. K., Metzel, P., & Corash, L. (2005) · Transfusion · doi:10.1111/j.0041-1132.2005.04316.x · Cited by 172
Mechanisms of mutation formation with long‐wave ultraviolet light (UVA)
Rünger, T. M., & Kappes, U. P. (2008) · Photodermatology, Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.2008.00319.x · Cited by 171
Ultraviolet Radiation and Melanoma
Kanavy, H. E., & Gerstenblith, M. R. (2011) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2011.08.003 · Cited by 170
Unravelling UVA-induced mutagenesis
Sage, E., Girard, P.-M., & Francesconi, S. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05219e · Cited by 167
Binding of Transcription Factors Creates Hot Spots for UV Photoproducts In Vivo
Pfeifer, G. P., Drouin, R., Riggs, A. D., & Holmquist, G. P. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.4.1798 · Cited by 160
Courdavault, S., Baudouin, C., Charveron, M., Canguilhem, B., Favier, A., Cadet, J., & Douki, T. (2005) · DNA Repair · doi:10.1016/j.dnarep.2005.05.001 · Cited by 156
Self-citationBesaratinia, A., Synold, T. W., Chen, H.-H., Chang, C., Xi, B., Riggs, A. D., & Pfeifer, G. P. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502311102 · Cited by 156
Besaratinia, A., Yoon, J., Schroeder, C., Bradforth, S. E., Cockburn, M., & Pfeifer, G. P. (2011) · The FASEB Journal · doi:10.1096/fj.11-187336 · Cited by 155
UVA-induced cyclobutane pyrimidine dimers in DNA: a direct photochemical mechanism?
Mouret, S., Philippe, C., Gracia-Chantegrel, J., Banyasz, A., Karpati, S., Markovitsi, D., & Douki, T. (2010) · Organic & Biomolecular Chemistry · doi:10.1039/b924712b · Cited by 149
Self-citationPsoralen and Ultraviolet A Light Therapy for Psoriasis
Stern, R. S. (2007) · New England Journal of Medicine · doi:10.1056/nejmct072317 · Cited by 149
Courdavault, S., Baudouin, C., Charveron, M., Favier, A., Cadet, J., & Douki, T. (2004) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2004.07.011 · Cited by 145
Self-citationPerrier, S., Hau, J., Gasparutto, D., Cadet, J., Favier, A., & Ravanat, J.-L. (2006) · Journal of the American Chemical Society · doi:10.1021/ja057656i · Cited by 141
Self-citationUVA1 induces cyclobutane pyrimidine dimers but not 6-4 photoproducts in human skin in vivo
Tewari, A., Sarkany, R. P., & Young, A. R. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.283 · Cited by 141
Gogniat, G., & Dukan, S. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01079-07 · Cited by 140
DNA damage spectra induced by photosensitization
Epe, B. (2011) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05190c · Cited by 137
Lin, J. S., Eder, M. L., & Weinmann, S. A. (2011) · Annals of Internal Medicine · doi:10.7326/0003-4819-154-3-201102010-00009 · Cited by 136
Human Telomeres Are Hypersensitive to UV-Induced DNA Damage and Refractory to Repair
Rochette, P. J., & Brash, D. E. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000926 · Cited by 133
Oxidation of Guanine in Cellular DNA by Solar UV Radiation: Biological Role†
Douki, T., Perdiz, D., Grof, P., Kuluncsics, Z., Moustacchi, E., Cadet, J., & Sage, E. (1999) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1999.tb07988.x · Cited by 133
Self-citationModification of DNA bases by photosensitized one-electron oxidation
Cadet, J. (1999) · International Journal of Radiation Biology · doi:10.1080/095530099140212 · Cited by 132
Self-citationReviews on sun exposure and artificial light and melanoma
Gandini, S., Autier, P., & Boniol, M. (2011) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2011.09.011 · Cited by 131
Zhang, X., Rosenstein, B. S., Wang, Y., Lebwohl, M., Mitchell, D. M., & Wei, H. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb01886.x · Cited by 129
Sunscreens with Titanium Dioxide (TiO2) Nano-Particles: A Societal Experiment
Jacobs, J. F., van de Poel, I., & Osseweijer, P. (2010) · NanoEthics · doi:10.1007/s11569-010-0090-y · Cited by 129
Thymine-Thymine Adduct as a Photoproduct of Thymine
Varghese, A. J., & Wang, S. Y. (1968) · Science · doi:10.1126/science.160.3824.186 · Cited by 128
Pyrimidine Bimolecular Photoproducts
Wang, S. Y. (1976) · Elsevier eBooks · doi:10.1016/b978-0-12-734601-4.50012-4 · Cited by 125
Role of mitochondria in ultraviolet-induced oxidative stress
Gniadecki, R., Thorn, T., Vičanová, J., Petersen, A., & Wulf, H. C. (2000) · Journal of Cellular Biochemistry · doi:10.1002/1097-4644(20010201)80:2 · Cited by 122
Early Events in UV Carcinogenesis—DNA Damage, Target Cells and Mutant p53 Foci†
De Gruijl, F. R., & Rebel, H. (2008) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2007.00275.x · Cited by 120
Melanocytes are deficient in repair of oxidative DNA damage and UV-induced photoproducts
Wang, H.-T., Choi, B., & Tang, M.-S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005244107 · Cited by 119
Young, A. R., Potten, C. S., Nikaido, O., Parsons, P. G., Boenders, J., Ramsden, J. M., & Chadwick, C. A. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00435.x · Cited by 117
Mutations of the p53 and PTCH gene in basal cell carcinomas: UV mutation signature and strand bias
Kim, M. (2002) · Journal of Dermatological Science · doi:10.1016/s0923-1811(01)00170-0 · Cited by 116 · cited 1×
“This received strong support from the delineation of mutagenic effects of UVB and UVA components (10–14) with the observation of UVB-induced C fi T transition and CC fi TT mutations at bipyrimidine sites in p53 genes of skin tumors (8,15).”
BackgroundChadwick, C. A., Potten, C. S., Nikaido, O., Matsunaga, T., Proby, C., & Young, A. R. (1995) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/1011-1344(94)07096-7 · Cited by 114
The Triplet Energy of Thymine in DNA
Bosca, F., Lhiaubet-Vallet, V., Cuquerella, M. C., Castell, J. V., & Miranda, M. A. (2006) · Journal of the American Chemical Society · doi:10.1021/ja060651g · Cited by 113
Mascio, P. D., Wefers, H., Do-Thi, H.-P., Lafleur, M. V. M., & Sies, H. (1989) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(89)90033-x · Cited by 113
Peak, J. G., & Peak, M. J. (1991) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(91)90121-4 · Cited by 113
Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light
Zhang, X., Jeffs, G., Ren, X., O’Donovan, P., Montaner, B., Perrett, C. M., Karran, P., & Xu, Y.-Z. (2007) · DNA Repair · doi:10.1016/j.dnarep.2006.11.003 · Cited by 110
Excited-State Dynamics in 6-Thioguanosine from the Femtosecond to Microsecond Time Scale
Reichardt, C., Guo, C., & Crespo-Hernández, C. E. (2011) · The Journal of Physical Chemistry B · doi:10.1021/jp112018u · Cited by 109
Besaratinia, A., Kim, S.-I., Bates, S. E., & Pfeifer, G. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610534104 · Cited by 107
Banyasz, A., Vayá, I., Changenet-Barret, P., Gustavsson, T., Douki, T., & Markovitsi, D. (2011) · Journal of the American Chemical Society · doi:10.1021/ja110879m · Cited by 106
Self-citationMinor contribution of direct ionization to DNA base damage inducedby heavy ions
Douki, T., Ravanat, J.-L., Pouget, J.-P., Testard, I., & Cadet, J. (2006) · International Journal of Radiation Biology · doi:10.1080/09553000600573788 · Cited by 106
Self-citationGallagher, R. P., Lee, T. K., Bajdik, C. D., & Borugian, M. (2010) · Chronic Diseases and Injuries in Canada · doi:10.24095/hpcdp.29.s1.04 · Cited by 103
Radical and Radical Ion Reactivity in Nucleic Acid Chemistry
Greenberg, M. M. (2009) · Wiley eBooks · doi:10.1002/9780470526279 · Cited by 101
UV Laser Photolysis of DNA: Effect of Duplex Stability on Charge-Transfer Efficiency
Douki, T., Angelov, D., & Cadet, J. (2001) · Journal of the American Chemical Society · doi:10.1021/ja016426a · Cited by 100
Self-citationLee, D.-H., & Pfeifer, G. P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212696200 · Cited by 99
UV INDUCED (6‐4) PHOTOPRODUCTS ARE DISTRIBUTED DIFFERENTLY THAN CYCLOBUTANE DIMERS IN NUCLEOSOMES
Gale, J. M., & Smerdon, M. J. (1990) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1990.tb01732.x · Cited by 98
Inter-strand photoproducts are produced in high yield within A-DNA exposed to UVC radiation
Douki, T. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg408 · Cited by 96
Self-citationPhotosensitized DNA Damage and its Protection via a Novel Mechanism†
Hiraku, Y., Ito, K., Hirakawa, K., & Kawanishi, S. (2007) · Photochemistry and Photobiology · doi:10.1562/2006-03-09-ir-840 · Cited by 95
Taylor, J., Garrett, D. S., & Cohrs, M. P. (1988) · Biochemistry · doi:10.1021/bi00419a007 · Cited by 94
Pflaum, M., Boiteux, S., & Epe, B. (1994) · Carcinogenesis · doi:10.1093/carcin/15.2.297 · Cited by 94
The specificity of UVA-induced DNA damage in human melanocytes
Mouret, S., Forestier, A., & Douki, T. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05185g · Cited by 94
Self-citationKim, S. W., & An, Y. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4153-6 · Cited by 94
UVA photosensitization of thiopurines and skin cancer in organ transplant recipients
Attard, N. R., & Karran, P. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05194f · Cited by 94
Thomas, D. C., Okumoto, D. S., Sancar, A., & Bohr, V. A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84671-9 · Cited by 94
Mouret, S., Charveron, M., Favier, A., Cadet, J., & Douki, T. (2008) · DNA Repair · doi:10.1016/j.dnarep.2008.01.005 · Cited by 92
Self-citationCannistraro, V. J., & Taylor, J. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.07.048 · Cited by 91
Wood, P. D., & Redmond, R. W. (1996) · Journal of the American Chemical Society · doi:10.1021/ja954340+ · Cited by 90
Harada, Y., Suzuki, T., Ichimura, T., & Xu, Y.-Z. (2007) · The Journal of Physical Chemistry B · doi:10.1021/jp0678094 · Cited by 90
Ultraviolet irradiation of titanium dioxide in aqueous dispersion generates singlet oxygen
Konaka, R., Kasahara, E., Dunlap, W. C., Yamamoto, Y., Chien, K. C., & Inoue, M. (2001) · Redox Report · doi:10.1179/135100001101536463 · Cited by 89
Meldrum, R. A., Botchway, S. W., Wharton, C. W., & Hirst, G. (2003) · EMBO Reports · doi:10.1038/sj.embor.7400028 · Cited by 89
Triplet Excited Fluoroquinolones as Mediators for Thymine Cyclobutane Dimer Formation in DNA
Lhiaubet‐Vallet, V., Cuquerella, M. C., Castell, J. V., Boscá, F., & Miranda, M. A. (2007) · The Journal of Physical Chemistry B · doi:10.1021/jp070167f · Cited by 84
193 NM LIGHT INDUCES SINGLE STRAND BREAKAGE OF DNA PREDOMINANTLY AT GUANINE
Melvin, T., Plumb, M., Botchway, S. W., O'Neill, P., & Parker, A. W. (1995) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1995.tb09873.x · Cited by 82
One-electron oxidation of DNA and inflammation processes
Cadet, J., Douki, T., & Ravanat, J. (2006) · Nature Chemical Biology · doi:10.1038/nchembio0706-348 · Cited by 82
Self-citationLemaire, D. G. E., & Ruzsicska, B. P. (1993) · Biochemistry · doi:10.1021/bi00061a009 · Cited by 81
Tada‐Oikawa, S., Oikawa, S., Hirayama, J., Hirakawa, K., & Kawanishi, S. (2009) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2009.00600.x · Cited by 80
Ikehata, H., Kawai, K., Komura, J.-I., Sakatsume, K., Wang, L., Imai, M., Higashi, S., Nikaido, O., Yamamoto, K., Hieda, K., et al. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.61 · Cited by 79
5-Methoxypsoralen: A Review of its Effects in Psoriasis and Vitiligo
McNeely, W., & Goa, K. L. (1998) · Drugs · doi:10.2165/00003495-199856040-00015 · Cited by 79
4-thiothymidine sensitization of DNA to UVA offers potential for a novel photochemotherapy
Reelfs, O., Karran, P., & Young, A. R. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05188a · Cited by 79
Sauvaigo, S., Douki, T., Odin, F., Caillat, S., Ravanat, J., & Cadet, J. (2001) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2001)073 · Cited by 79
Self-citationThe Insulated SolarFenton Hybrid Process: Fundamental Investigations
Sagawe, G., Lehnard, A., Lübber, M., & Bahnemann, D. W. (2001) · Helvetica Chimica Acta · doi:10.1002/1522-2675(20011219)84:12 · Cited by 78
Sheu, C., Kang, P., Khan, S., & Foote, C. S. (2002) · Journal of the American Chemical Society · doi:10.1021/ja011696e · Cited by 78
Mechanism of UV‐Induced Formation of Dewar Lesions in DNA
Haiser, K., Fingerhut, B. P., Heil, K., Glas, A. F., Herzog, T. T., Pilles, B. M., Schreier, W. J., Zinth, W., de Vivie‐Riedle, R., & Carell, T. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201106231 · Cited by 78
Formation and stability of repairable pyrimidine photohydrates in DNA
Boorstein, R. J., Hilbert, T. P., Cunningham, R. P., & Teebor, G. W. (1990) · Biochemistry · doi:10.1021/bi00498a004 · Cited by 77
Multiple forms of DNA Damage Caused by UVA Photoactivation of DNA 6‐Thioguanine
Brem, R., & Karran, P. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2011.01043.x · Cited by 76
Douki, T., Court, M., & Cadet, J. (2000) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(00)00009-9 · Cited by 75
Self-citationHuang, X., Bernerd, F., & Halliday, G. M. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080318 · Cited by 73
Lhiaubet, V., Paillous, N., & Chouini-Lalanne, N. (2007) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2001)0740670coddpb2.0.co2 · Cited by 72
Douki, T., & Cadet, J. (1994) · Biochemistry · doi:10.1021/bi00205a033 · Cited by 72
Self-citationPHOTOSENSITIZATION OF PYRIMIDINES BY 2‐METHYLNAPHTHOQUINONE IN WATER: A LASER FLASH PHOTOLYSIS STUDY
Fisher, G. J., & Land, E. J. (1983) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1983.tb04429.x · Cited by 72
Photosensitized DNA Damage: The Case of Fluoroquinolones†
Lhiaubet‐Vallet, V., Boscá, F., & Miranda, M. A. (2009) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2009.00548.x · Cited by 71
Cao, H., Hearst, J. E., Corash, L., & Wang, Y. (2008) · Analytical Chemistry · doi:10.1021/ac7023969 · Cited by 70
Delatour, T., Douki, T., D'Ham, C., & Cadet, J. (1998) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(98)00142-0 · Cited by 70
Self-citationMarrot, L., Belaïdi, J. P., Jones, C., Perez, P., Meunier, J. R., Riou, L., & Sarasin, A. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12422.x · Cited by 70
Lai, C., Cao, H., Hearst, J. E., Corash, L., Luo, H., & Wang, Y. (2008) · Analytical Chemistry · doi:10.1021/ac801520m · Cited by 70
Rosen, J. E., Prahalad, A. K., & Williams, G. M. (1996) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1996.tb02430.x · Cited by 68
Brem, R., Li, F., & Karran, P. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp070 · Cited by 67
Psoralen Photochemistry and Nucleic Acid Structure
Hearst, J. E. (1981) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12479229 · Cited by 66
Guanine is the target for direct ionisation damage in DNA, as detected using excision enzymes
Melvin, T. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.21.4935 · Cited by 66
Sunblocks: Mechanisms of action
Murphy, G. M. (1999) · Photodermatology, Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.1999.tb00051.x · Cited by 62
Extracorporeal photochemoimmunotherapy in cutaneous T-cell lymphoma
Knobler, R., & Jantschitsch, C. (2003) · Transfusion and Apheresis Science · doi:10.1016/s1473-0502(02)00103-9 · Cited by 61
Stiffness Alterations of Single Cells Induced by UV in the Presence of NanoTiO2
Vileno, B., Lekka, M., Sienkiewicz, A., Jeney, S., Stoessel, G., Lekki, J., Forró, L., & Stachura, Z. (2007) · Environmental Science & Technology · doi:10.1021/es0629561 · Cited by 60
Photosensitization Reactions of Fluoroquinolones and Their Biological Consequences
Guidi, G. D., Bracchitta, G., & Catalfo, A. (2011) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2011.00978.x · Cited by 60
DNA−Protein Cross-Linking from Oxidation of Guanine via the Flash−Quench Technique
Nguyen, K. L., Steryo, M., Kurbanyan, K., Nowitzki, K. M., Butterfield, S. M., Ward, S. R., & Stemp, E. D. A. (2000) · Journal of the American Chemical Society · doi:10.1021/ja993502p · Cited by 59
Effects of Duplex Stability on Charge-Transfer Efficiency within DNA
Douki, T., Ravanat, J., Angelov, D., Wagner, J. R., & Cadet, J. (2012) · Topics in current chemistry · doi:10.1007/b94409 · Cited by 57
Self-citationSpecific local induction of DNA strand breaks by infrared multi-photon absorption
Träutlein, D., Deibler, M., Leitenstorfer, A., & Ferrando‐May, E. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp932 · Cited by 57
Photocrosslinking of human telomeric G-quadruplex loops by anti cyclobutane thymine dimer formation
Su, D. G. T., Fang, H., Gross, M. L., & Taylor, J.-S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902386106 · Cited by 55
Ren, X., Li, F., Jeffs, G., Zhang, X., Xu, Y.-Z., & Karran, P. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp1165 · Cited by 55
Zhang, Y., Zhu, X., Smith, J., Haygood, M. T., & Gao, R. (2011) · The Journal of Physical Chemistry B · doi:10.1021/jp109590t · Cited by 53
DNA−Protein Cross-Linking via Guanine Oxidation: Dependence upon Protein and Photosensitizer
Kurbanyan, K., Nguyen, K. L., To, P., Rivas, E. V., Lueras, A. M. K., Kosinski, C., Steryo, M., González, A., Mah, D. A., & Stemp, E. D. A. (2003) · Biochemistry · doi:10.1021/bi020713p · Cited by 53
Photochemical Properties of Ofloxacin Involved in Oxidative DNA Damage: A Comparison with Rufloxacin
Cuquerella, M. C., Boscá, F., Miranda, M. A., Belvedere, A., Catalfo, A., & de Guidi, G. (2003) · Chemical Research in Toxicology · doi:10.1021/tx034006o · Cited by 53
Effects of UV and Visible Radiations on Cellular DNA
Cadet, J., Douki, T., Pouget, J., Ravanat, J., & Sauvaigo, S. (2000) · KARGER eBooks · doi:10.1159/000060654 · Cited by 51
Self-citationNussbaumer, W., Allersdorfer, D., Grabmer, C., Rheinschmidt, M., Lin, L., Schönitzer, D., & Lass‐Flörl, C. (2007) · Transfusion · doi:10.1111/j.1537-2995.2007.01247.x · Cited by 51
No formation of DNA double-strand breaks and no activation of recombination repair with UVA
Rizzo, J. L., Dunn, J., Rees, A., & Rünger, T. M. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.365 · Cited by 50
Recruitment of DNA repair synthesis machinery to sites of DNA damage/repair in living human cells
Hashiguchi, K., Matsumoto, Y., & Yasui, A. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm115 · Cited by 49
Efficient DNA interstrand crosslinking by 6-thioguanine and UVA radiation
Brem, R., Daehn, I., & Karran, P. (2011) · DNA Repair · doi:10.1016/j.dnarep.2011.05.010 · Cited by 48
Moysan, A., Viari, A., Vigny, P., Voituriez, L., Cadet, J., Moustacchi, E., & Sage, É. (1991) · Biochemistry · doi:10.1021/bi00243a007 · Cited by 47
Self-citationGueranger, Q., Kia, A., Frith, D., & Karran, P. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr112 · Cited by 47
Significance of CpG Methylation for Solar UV‐Induced Mutagenesis and Carcinogenesis in Skin‡
Ikehata, H., & Ono, T. (2006) · Photochemistry and Photobiology · doi:10.1562/2006-02-28-ir-822 · Cited by 46
Individual Photosensitivity of Human Skin and UVA-Induced Pyrimidine Dimers in DNA
Mouret, S., Leccia, M. ‐., Bourrain, J. ‐., Douki, T., & Béani, J. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.47 · Cited by 44
Self-citationKassam, S. N., & Rainbow, A. J. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.06.005 · Cited by 43
Brem, R., Li, F., Montaner, B., Reelfs, O., & Karran, P. (2010) · Oncogene · doi:10.1038/onc.2010.140 · Cited by 42
Singlet oxygen induces oxidation of cellular DNA.
Ravanat, J.-L., Di Mascio, P., Martinez, G. R., Medeiros, M. G., & Cadet, J. (2001) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)46360-6 · Cited by 42
Self-citationFunctional characteristics of photochemically treated platelets
Jansen, G. A. J., Van Vliet, H. H. D. M., Vermeij, H., Beckers, E. A. M., Leebeek, F. W. G., Sonneveld, P., & Van Rhenen, D. J. (2004) · Transfusion · doi:10.1111/j.1537-2995.2003.00588.x · Cited by 41
Hendriks, G., Calléja, F., Besaratinia, A., Vrieling, H., Pfeifer, G. P., Mullenders, L. H. F., Jansen, J. G., & de Wind, N. (2010) · Current Biology · doi:10.1016/j.cub.2009.11.061 · Cited by 39
Measurement of oxidatively generated base damage to nucleic acids in cells: facts and artifacts
Cadet, J., Douki, T., Ravanat, J.-L., & Wagner, J. R. (2012) · Bioanalytical Reviews · doi:10.1007/s12566-012-0029-6 · Cited by 38
Self-citationThe Repair of DNA Damages Induced in Normal Human Skin Fibroblasts Exposed to Simulated Sunlight
Rosenstein, B. S., & Mitchell, D. L. (1991) · Radiation Research · doi:10.2307/3577923 · Cited by 38
Melvin, T., Cunniffe, S. M. T., Papworth, D. G., Roldán‐Arjona, T., & O'Neill, P. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb01908.x · Cited by 37
Reelfs, O., Macpherson, P., Ren, X., Xu, Y.-Z., Karran, P., & Young, A. R. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr674 · Cited by 36
Costalat, R., Blais, J., Ballini, J., Moysan, A., Cadet, J., CHALVET, O., & Vigny, P. (1990) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1990.tb01709.x · Cited by 35
Self-citationEndonuclease-sensitive DNA modifications induced by acetone and acetophenone as photosensitizers
Epe, B., Henzl, H., Adam, W., & Saha-Möller, C. R. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.4.863 · Cited by 33
Belvedere, A., Boscá, F., Catalfo, A., Cuquerella, M. C., de Guidi, G., & Miranda, M. A. (2002) · Chemical Research in Toxicology · doi:10.1021/tx025530i · Cited by 33
Crystal structure of a thymine–thymine adduct from irradiated thymine
Karle, I. L. (1969) · Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry · doi:10.1107/s056774086900522x · Cited by 33
Mitchell, D. L., Allison, J. P., & Nairn, R. S. (1990) · Radiation Research · doi:10.2307/3577736 · Cited by 32
Kang, S. J., Lee, Y. J., Kim, B. M., et al. (2011) · Drug and Chemical Toxicology · doi:10.3109/01480545.2010.546800 · Cited by 30
Reelfs, O., Xu, Y.-Z., Massey, A., Karran, P., & Storey, A. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0166 · Cited by 30
Lu, Z.-X., Zhang, Z.-L., Zhang, M.-X., Xie, H.-Y., Tian, Z.-Q., Chen, P., Huang, H., & Pang, D.-W. (2005) · The Journal of Physical Chemistry B · doi:10.1021/jp054472h · Cited by 29
Swetha, S., Santhosh, S. M., & Geetha Balakrishna, R. (2010) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2010.00781.x · Cited by 28
Discovery and Synthesis of New UV-Induced Intrastrand C(4−8)G and G(8−4)C Photolesions
Münzel, M., Szeibert, C., Glas, A. F., Globisch, D., & Carell, T. (2011) · Journal of the American Chemical Society · doi:10.1021/ja111304f · Cited by 28
Extent of formation of a dimeric adenine photoproduct in polynucleotides and DNA
Sharma, N. D., & Davies, R. J. H. (1989) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/1011-1344(89)80066-1 · Cited by 27
Traynor, N. J., & Gibbs, N. K. (1999) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1999.tb08308.x · Cited by 26
The Photochemistry of Thymidylyl-(3'-5')- 5-methyl-2'-deoxycytidine in Aqueous Solution
Celewicz, L., Mayer, M., & Shetlar, M. D. (2004) · Photochemistry and Photobiology · doi:10.1562/2004-06-15-ra-201.1 · Cited by 26
The photobiology of melanocytes modulates the impact of UVA on sunlight-induced melanoma
Mitchell, D. L., & Fernandez, A. A. (2011) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05146f · Cited by 26
Smith, S. I., & Brodbelt, J. S. (2010) · The Analyst · doi:10.1039/b924023c · Cited by 25 · cited 1×
“UV ⁄ESI-MS or IR multiphoton dissociation mass spectrometry has recently become available (173).”
Pinto, A. V., Deodato, E. L., Cardoso, J. S., Oliveira, E. F., Machado, S. L., Toma, H. K., Leitão, A. C., & de Pádula, M. (2010) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2010.02.003 · Cited by 25
Song, Q., Cannistraro, V. J., & Taylor, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.183178 · Cited by 25
Photopheresis in the treatment of cutaneous T-cell lymphoma: current status
Zic, J. A. (2012) · Current Opinion in Oncology · doi:10.1097/01.cco.0000410158.56500.c4 · Cited by 25
Flagged first, then by citations
Research works printed but not linked: 4
- Cadet J., 1990, Bioorganic Photochemistry: Photochemistry and the Nucleic Acids, 1
- Kochevar I. E., Bioorganic Photochemistry: Photochemistry and the Nucleic Acids, 273
- 10.1021/ja954340 · DOI · Paper page
- Brankmann M., 1989, UVA‐induced 8‐MOP binding to cells of Saccharomyces cerevisiae, J. Photochem. Photobiol. B, Biol., 3, 59
Cited by
Sorted by citations
DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation
Cadet, J., & Wagner, J. R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012559 · Cited by 903
Self-citationFormation of UV-induced DNA damage contributing to skin cancer development
Cadet, J., & Douki, T. (2018) · Photochemical & Photobiological Sciences · doi:10.1039/c7pp00395a · Cited by 435
Self-citationSunlight damage to cellular DNA: focus on oxidatively generated lesions
Schuch, A. P., Moreno, N. C., Schuch, N. J., Menck, C. F. M., & Garcia, C. C. M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.029 · Cited by 436
Oxidatively Generated Damage to Cellular DNA by UVB and UVA Radiation ,
Cadet, J., Douki, T., & Ravanat, J. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12368 · Cited by 355
Self-citationEarly Events of DNA Photodamage
Schreier, W. J., Gilch, P., & Zinth, W. (2015) · Annual Review of Physical Chemistry · doi:10.1146/annurev-physchem-040214-121821 · Cited by 221
Metadata
- Authors
- Cadet, J., Mouret, S., Ravanat, J., & Douki, T.
- Affiliations
- Université Joseph Fourier (FR)
- Corresponding author
- Cadet, Jean
- Douki, Thierry
- Venue
- Photochemistry and Photobiology
- Publisher
- Wiley
- Published
- 2012-08-30
- Volume
- 88
- Issue
- 5
- Pages
- 1048-1065
- ISSN
- 0031-8655 (ISSN-L)
- 1751-1097
- OpenAlex
- W2090287369
- Semantic Scholar
- 85d02c35f95a00966e70c7fb04d83874dd606a9e
- Cited by
- 300
- References
- 232
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 20 · 2023: 11 · 2022: 19 · 2021: 22 · 2020: 20 · 2019: 17 · 2018: 23 · 2017: 28 · 2016: 34 · 2015: 16 · 2014: 42 · 2013: 25 · 2012: 1
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Photochemistry and Photobiology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- photoinduced DNA damage, cyclobutane pyrimidine dimers, UVA, UV-B radiation, photodynamic effect, DNA repair, photodamaged skin, mutagenicity
- MeSH terms
- Animals, DNA, DNA Damage, DNA Repair, Cricetinae, Humans, Oxidation-Reduction, Pyrimidine Dimers, Skin, Sunlight, Ultraviolet Rays, Keratinocytes, CHO Cells, Photosensitizing Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-05, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-05 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
