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Nanocarriers as an emerging platform for cancer therapy
Abstract
Nanotechnology has the potential to revolutionize cancer diagnosis and therapy. Advances in protein engineering and materials science have contributed to novel nanoscale targeting approaches that may bring new hope to cancer patients. Several therapeutic nanocarriers have been approved for clinical use. However, to date, there are only a few clinically approved nanocarriers that incorporate molecules to selectively bind and target cancer cells. This review examines some of the approved formulations and discusses the challenges in translating basic research to the clinic. We detail the arsenal of nanocarriers and molecules available for selective tumour targeting, and emphasize the challenges in cancer treatment.
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“Furthermore, their capability to co-delivering therapeutics and diagnostic reagents, which have greatly promoted the development of theranostics and smart nanoparticles for cancer therapy.13”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [13]
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“In contrast to easily diffusible free drugs, a nanocarrier can penetrate into the tumor tissue through the leaky vasculature due to the enhanced permeation and retention effect.225”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [225]
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“Meanwhile, many types of ligands, such as folate, transferrin, antibody and aptamer, etc., can also be incorporated into the non-viral vectors to boost cellular uptake via receptor-mediated endocytosis [171–173].”
From Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities (2018) · cites this paper as [172]
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Metadata
- Authors
- Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Massachusetts Institute of Technology (US)
- Tel Aviv University (IL)
- Venue
- Nature Nanotechnology
- Published
- 2007-12
- Volume
- 2
- Issue
- 12
- Pages
- 751-760
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2032760352
- Cited by
- 8,710
- References
- 106
- Citations by year
- 2026: 315 · 2025: 354 · 2024: 357 · 2023: 383 · 2022: 454 · 2021: 563 · 2020: 618 · 2019: 607 · 2018: 686 · 2017: 677 · 2016: 659 · 2015: 664 · 2014: 600 · 2013: 536 · 2012: 453
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Nanotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5u54ca119349-05)
- National Cancer Institute (CA 119349)
- National Institute of Biomedical Imaging and Bioengineering (K08EB003647, R01EB000244, EB003647)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- nanocarriers, cancer therapy, tumor targeting, targeted drug delivery, clinical translation, nanomedicine, cancer diagnosis
- MeSH terms
- Antineoplastic Agents, Drug Carriers, Drug Compounding, Neoplasms, Nanostructures, Nanomedicine
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