Cited by 99Neuroendocrine regulation and behaviorStress Responses and CortisolNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 203 of the 204 references it cites were found in a registry or an index.

Oxytocin and Stress-related Disorders: Neurobiological Mechanisms and Treatment Opportunities

Open access

Sippel, Lauren M., Allington, Casey E., Pietrzak, Robert H., Harpaz-Rotem, Ilan, Mayes, Linda C., Olff, Miranda·2017·Chronic Stress

DOI 10.1177/2470547016687996PMC PMC5482285

Open this paper in CoChat — free account

Abstract

Novel pharmacotherapies that improve outcomes for individuals with stress-related psychiatric disorders are needed. The neurohormone oxytocin (OT) is a promising candidate given its influence on the social–emotional brain. In this review, we present an overview of evidence supporting OT’s utility for treating major depressive disorder and posttraumatic stress disorder. We first discuss endogenous OT, which research suggests is not yet a reliable biomarker of stress-related disorders. Second, we review effects of intranasal (IN) OT on processes relevant to stress-related disorders in healthy populations (anhedonia, reward processing, psychosocial stress reactivity, fear/anxiety, and social behavior) and their neurobiological mechanisms (e.g., the salience network and hypothalamic–pituitary–adrenal axis). Third, we present the sparse but promising findings from clinical populations, followed by discussion of critical moderating variables to consider in the service of maximizing the therapeutic potential of OT (e.g., patient sex and child maltreatment). We also identify heterogeneous findings and limitations of existing research, including reliance on single-dose studies in psychiatrically healthy samples and unanswered questions regarding the effectiveness of IN drug delivery and dosing schedules. Well-controlled multidose studies including women and measures of potentially moderating variables are sorely needed and would inform our understanding of the utility of OT for preventing and treating stress-related psychiatric disorders.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1177/2470547016687996

Cites

203 of 203 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: Effect of intranasal oxytocin administration on psychiatric symptoms: A meta-analysis of placebo-controlled studies
Hofmann, S. G., Fang, A., & Brager, D. N. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.05.039 · Cited by 44
Retracted
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
Dissociable intrinsic connectivity networks for salience processing and executive control
Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426
Research domain criteria (RDoC): toward a new classification framework for research on mental disorders
Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., Sanislow, C., & Wang, P. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091379 · Cited by 7,067
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.
Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206
Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091
A Multidimensional Meta-Analysis of Psychotherapy for PTSD
Bradley, R., Greene, J., Russ, E., Dutra, L., & Westen, D. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.2.214 · Cited by 1,938
The link between childhood trauma and depression: insights from HPA axis studies in humans
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.008 · Cited by 1,704
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639
Social effects of oxytocin in humans: context and person matter
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.002 · Cited by 1,581 · cited 2×
“Observations of null and inconsistent main effects of IN OT led to the recognition that OT effects, like those of many pharmacologics, are often moderated by characteristics of the individuals to whom IN OT is administered, as well as the context in which the medication is administered.(95)”
BackgroundResult
Sex differences in anxiety and depression clinical perspectives
Altemus, M., Sarvaiya, N., & Neill Epperson, C. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.05.004 · Cited by 1,413
Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U., & Fehr, E. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.009 · Cited by 1,258
Depression, Stress, and Anhedonia: Toward a Synthesis and Integrated Model
Pizzagalli, D. A. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050212-185606 · Cited by 1,155
The Neuropeptide Oxytocin Regulates Parochial Altruism in Intergroup Conflict Among Humans
De Dreu, C. K. W., Greer, L. L., Handgraaf, M. J. J., Shalvi, S., Van Kleef, G. A., Baas, M., Ten Velden, F. S., Van Dijk, E., & Feith, S. W. W. (2010) · Science · doi:10.1126/science.1189047 · Cited by 1,148
Evoked axonal oxytocin release in the central amygdala attenuates fear response
Knobloch, H. S., Charlet, A., Hoffmann, L. C., Eliava, M., Khrulev, S., Cetin, A. H., Osten, P., Schwarz, M. K., Seeburg, P. H., Stoop, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.030 · Cited by 1,049
Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors
Neumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954
An attachment perspective on psychopathology
Mikulincer, M., & Shaver, P. (2012) · World Psychiatry · doi:10.1016/j.wpsyc.2012.01.003 · Cited by 932
The Social Salience Hypothesis of Oxytocin
Shamay-Tsoory, S. G., & Abu-Akel, A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.020 · Cited by 904 · cited 1×
“Increasing the salience of social cues in different contexts may have different implications for emotional and social well-being.(94) In positive social contexts, INOTmay be beneficial for remediating stress-related psychiatric symptoms, but in negative contexts, INOTmay exacerbate sensitivity to negative cues and inc…”
Background
Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles
Insel, T. R., & Shapiro, L. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5981 · Cited by 833
Intranasal Oxytocin Increases Positive Communication and Reduces Cortisol Levels During Couple Conflict
Ditzen, B., Schaer, M., Gabriel, B., Bodenmann, G., Ehlert, U., & Heinrichs, M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.011 · Cited by 805
Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
Huber, D., Veinante, P., & Stoop, R. (2005) · Science · doi:10.1126/science.1105636 · Cited by 804
Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans
Hurlemann, R., Patin, A., Onur, O. A., Cohen, M. X., Baumgartner, T., Metzler, S., Dziobek, I., Gallinat, J., Wagner, M., Maier, W., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5538-09.2010 · Cited by 771
Tend and Befriend: Biobehavioral Bases of Affiliation Under Stress
Taylor, S. E. (2006) · Current Directions in Psychological Science · doi:10.1111/j.1467-8721.2006.00451.x · Cited by 755
Stress and the social brain: behavioural effects and neurobiological mechanisms
Sandi, C., & Haller, J. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3918 · Cited by 657
The organization of the stress system and its dysregulation in depressive illness
Gold, P. W. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.163 · Cited by 654
A meta-analysis of the magnitude of biased attention in depression
Peckham, A. D., McHugh, R. K., & Otto, M. W. (2010) · Depression and Anxiety · doi:10.1002/da.20755 · Cited by 647
The role of oxytocin in social bonding, stress regulation and mental health: an update on the moderating effects of context and interindividual differences
Olff, M., Frijling, J. L., Kubzansky, L. D., Bradley, B., Ellenbogen, M. A., Cardoso, C., Bartz, J. A., Yee, J. R., & van Zuiden, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.019 · Cited by 620
Self-citation
Intranasal Oxytocin: Myths and Delusions
Leng, G., & Ludwig, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.003 · Cited by 616 · cited 1×
“IN OT may thus enter the central nervous system, mimicking ‘‘neurohormonal’’ OT release; alternatively, IN OT may act peripherally to affect behavior via OT receptors.(25) The presence of OT receptors in many sites in the periphery suggest that it has broad effects,(25) but possible long-term neuronal and molecular si…”
Background
Reward and Punishment Processing in Depression
Eshel, N., & Roiser, J. P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.01.027 · Cited by 575
A common allele in the oxytocin receptor gene ( OXTR ) impacts prosocial temperament and human hypothalamic-limbic structure and function
Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., Mattay, V. S., Weinberger, D. R., & Meyer–Lindenberg, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003296107 · Cited by 564
Intranasal Administration of Oxytocin Increases Envy and Schadenfreude (Gloating)
Shamay-Tsoory, S. G., Fischer, M., Dvash, J., Harari, H., Perach-Bloom, N., & Levkovitz, Y. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.009 · Cited by 542 · cited 1×
“For example, IN OT was found to be associated with increased approach toward angry faces,(90) increased inclinations toward intimate partner violence in trait aggressive individuals,(91) increased aggressive behavior,(92) and increased envy and gloating.(93) IN OT is proposed to enhance socially salient cues, with sal…”
Background
Effects of different kinds of couple interaction on cortisol and heart rate responses to stress in women
Ditzen, B., Neumann, I. D., Bodenmann, G., von Dawans, B., Turner, R. A., Ehlert, U., & Heinrichs, M. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.03.011 · Cited by 525
Effects of intranasal oxytocin on emotional face processing in women
Domes, G., Lischke, A., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., & Herpertz, S. C. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.016 · Cited by 521
Lower CSF oxytocin concentrations in women with a history of childhood abuse
Heim, C., Young, L. J., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.112 · Cited by 518
Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice
Neumann, I. D., Maloumby, R., Beiderbeck, D. I., Lukas, M., & Landgraf, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.003 · Cited by 511
Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans
Gamer, M., Zurowski, B., & Büchel, C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000985107 · Cited by 487
Influence of a “Warm Touch” Support Enhancement Intervention Among Married Couples on Ambulatory Blood Pressure, Oxytocin, Alpha Amylase, and Cortisol
Holt-Lunstad, J., Birmingham, W. A., & Light, K. C. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318187aef7 · Cited by 473
Oxytocin in general anxiety and social fear: a translational approach
Neumann, I. D., & Slattery, D. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.004 · Cited by 468
Relations among posttraumatic stress disorder, comorbid major depression, and HPA function: A systematic review and meta-analysis
Morris, M. C., Compas, B. E., & Garber, J. (2012) · Clinical Psychology Review · doi:10.1016/j.cpr.2012.02.002 · Cited by 466
Oxytocin can hinder trust and cooperation in borderline personality disorder
Bartz, J., Simeon, D., Hamilton, H., Kim, S., Crystal, S., Braun, A., Vicens, V., & Hollander, E. (2011) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq085 · Cited by 452
Psychosocial buffers of traumatic stress, depressive symptoms, and psychosocial difficulties in veterans of Operations Enduring Freedom and Iraqi Freedom: the role of resilience, unit support, and postdeployment social support.
Pietrzak, R. H., Johnson, D. C., Goldstein, M. B., Malley, J. C., Rivers, A. J., Morgan, C. A., & Southwick, S. M. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.04.015 · Cited by 447
Self-citation
CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior
Bale, T. L., Davis, A. M., Auger, A. P., Dorsa, D. M., & McCarthy, M. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-07-02546.2001 · Cited by 446
Oxytocin selectively improves empathic accuracy
Bartz, J. A., Zaki, J., Bolger, N., Hollander, E., Ludwig, N. N., Kolevzon, A., & Ochsner, K. N. (2010) · Psychological Science · doi:10.1177/0956797610383439 · Cited by 442
Acute effects of steroid hormones and neuropeptides on human social-emotional behavior: A review of single administration studies
Bos, P. A., Panksepp, J., Bluthé, R.-M., & Honk, J. V. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.01.002 · Cited by 429
Oxytocin Attenuates Affective Evaluations of Conditioned Faces and Amygdala Activity
Petrovic, P., Kalisch, R., Singer, T., & Dolan, R. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4572-07.2008 · Cited by 424 · cited 1×
“IN OT has also been found to reduce amygdala activation in modulation of autonomic fear(73) and in response to stimuli that were aversively conditioned.(74) Meta-analytic findings suggest that IN OT increases activity in prefrontal cortical areas that mediate emotion regulation and fear inhibition.”
Background
Problems with measuring peripheral oxytocin: can the data on oxytocin and human behavior be trusted?
McCullough, M. E., Churchland, P. S., & Mendez, A. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.018 · Cited by 416
Sniffing around oxytocin: Review and meta-analyses of trials in healthy and clinical groups with implications for pharmacotherapy
Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.34 · Cited by 383
Dopamine and Oxytocin Interactions Underlying Behaviors: Potential Contributions to Behavioral Disorders
Baskerville, T. A., & Douglas, A. J. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00154.x · Cited by 377
Prospective Study of Posttraumatic Stress, Anxiety, and Depressive Reactions After Earthquake and Political Violence
Goenjian, A. K., Steinberg, A. M., Najarian, L. M., Fairbanks, L. A., Tashjian, M., & Pynoos, R. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.6.911 · Cited by 376
Oxytocin, motivation and the role of dopamine
Love, T. M. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.06.011 · Cited by 369
Acute stress reduces reward responsiveness: Implications for depression
Bogdan, R., & Pizzagalli, D. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.037 · Cited by 364
A review of safety, side-effects and subjective reactions to intranasal oxytocin in human research
MacDonald, E., Dadds, M. R., Brennan, J. L., Williams, K., Levy, F., & Cauchi, A. J. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.02.015 · Cited by 359 · cited 1×
“To date, most experimental research on OT has utilized intranasal administration (IN OT) given its convenience, noninvasiveness, and safety.(44) IN OT pharmacokinetics are not fully understood, and definitive evidence for how much OT, a large peptide, reaches target brain areas via IN delivery is lacking;(23) however,…”
Background
Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research
Guastella, A. J., Hickie, I. B., McGuinness, M. M., Otis, M., Woods, E. A., Disinger, H. M., Chan, H.-K., Chen, T. F., & Banati, R. B. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.11.019 · Cited by 357
Oxytocin Pathway Genes: Evolutionary Ancient System Impacting on Human Affiliation, Sociality, and Psychopathology
Feldman, R., Monakhov, M., Pratt, M., & Ebstein, R. P. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.08.008 · Cited by 352
Guilt, fear, submission, and empathy in depression
O’Connor, L. E., Berry, J. W., Weiss, J., & Gilbert, P. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00408-6 · Cited by 349
Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies
Walum, H., Waldman, I. D., & Young, L. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.016 · Cited by 347 · cited 1×
“Improved research standards including increased statistical power and reporting on trials without expected results are needed before IN OT can be utilized as a first-line treatment for stress-related disorders.(201)”
Background
Dissociated central and peripheral release of vasopressin, but not oxytocin, in response to repeated swim stress: New insights into the secretory capacities of peptidergic neurons
Wotjak, C. T., Ganster, J., Kohl, G., Holsboer, F., Landgraf, R., & Engelmann, M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00683-0 · Cited by 345
Sex differences in the neural and behavioral response to intranasal oxytocin and vasopressin during human social interaction
Rilling, J. K., DeMarco, A. C., Hackett, P. D., Chen, X., Gautam, P., Stair, S., Haroon, E., Thompson, R., Ditzen, B., Patel, R., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.022 · Cited by 343
Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking
Kim, H. S., Sherman, D. K., Sasaki, J. Y., Xu, J., Chu, T. Q., Ryu, C., Suh, E. M., Graham, K., & Taylor, S. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010830107 · Cited by 341
Oxytocin enhances brain reward system responses in men viewing the face of their female partner
Scheele, D., Wille, A., Kendrick, K. M., Stoffel-Wagner, B., Becker, B., Güntürkün, O., Maier, W., & Hurlemann, R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314190110 · Cited by 340
Oxytocin during the initial stages of romantic attachment: Relations to couples’ interactive reciprocity
Schneiderman, I., Zagoory-Sharon, O., Leckman, J. F., & Feldman, R. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.12.021 · Cited by 333
Oxytocin and social perception: oxytocin increases perceived facial trustworthiness and attractiveness
Theodoridou, A., Rowe, A. C., Penton-Voak, I. S., & Rogers, P. J. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.03.019 · Cited by 318
Does Oxytocin Increase Trust in Humans? A Critical Review of Research
Nave, G., Camerer, C., & McCullough, M. (2015) · Perspectives on Psychological Science · doi:10.1177/1745691615600138 · Cited by 316 · cited 1×
“of these latter results have been challenged.(85) IN OT has also been linked to increased willingness to share emotions related to a painful memory,(86) increased recall of positive social affiliation memories,(87) and indicators of pair bonding and relationship outcomes.”
Result
Salivary Cortisol Levels in Persons With and Without Different Anxiety Disorders
Vreeburg, S. A., Zitman, F. G., van Pelt, J., DeRijk, R. H., Verhagen, J. C. M., van Dyck, R., Hoogendijk, W. J. G., Smit, J. H., & Penninx, B. W. J. H. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181d2f0c8 · Cited by 312
Oxytocin Modulates Social Distance between Males and Females
Scheele, D., Striepens, N., Güntürkün, O., Deutschländer, S., Maier, W., Kendrick, K. M., & Hurlemann, R. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2755-12.2012 · Cited by 301 · cited 11×
“Severity and course of MDD may also be meaningful qualifiers for use of IN OT.”
BackgroundInfluential
The impact of a single administration of intranasal oxytocin on the recognition of basic emotions in humans: A meta-analysis
Shahrestani, S., Kemp, A. H., & Guastella, A. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.86 · Cited by 283
Prosocial effects of oxytocin and clinical evidence for its therapeutic potential
Striepens, N., Kendrick, K. M., Maier, W., & Hurlemann, R. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.07.001 · Cited by 283
Oxytocin enhances the experience of attachment security
Buchheim, A., Heinrichs, M., George, C., Pokorny, D., Koops, E., Henningsen, P., O’Connor, M.-F., & Gündel, H. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.04.002 · Cited by 277
Oxytocin, stress and social behavior: neurogenetics of the human oxytocin system
Kumsta, R., & Heinrichs, M. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.09.004 · Cited by 276
PTSD is associated with an excess of inflammatory immune activities
Gill, J. M., Saligan, L., Woods, S., & Page, G. (2009) · Perspectives in Psychiatric Care · doi:10.1111/j.1744-6163.2009.00229.x · Cited by 271
Common oxytocin receptor gene ( OXTR ) polymorphism and social support interact to reduce stress in humans
Chen, F. S., Kumsta, R., von Dawans, B., Monakhov, M., Ebstein, R. P., & Heinrichs, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113079108 · Cited by 268
The Role of Oxytocin in Psychiatric Disorders: A Review of Biological and Therapeutic Research Findings
Cochran, D. M., Fallon, D., Hill, M., & Frazier, J. A. (2013) · Harvard Review of Psychiatry · doi:10.1097/hrp.0b013e3182a75b7d · Cited by 267
Social facilitation of wound healing
Detillion, C. E., Craft, T. K. S., Glasper, E. R., Prendergast, B. J., & DeVries, A. C. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2003.10.003 · Cited by 259
Reward functioning in PTSD: a systematic review exploring the mechanisms underlying anhedonia
Nawijn, L., van Zuiden, M., Frijling, J. L., Koch, S. B. J., Veltman, D. J., & Olff, M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.01.019 · Cited by 250
Self-citation
Salivary oxytocin concentrations in response to running, sexual self-stimulation, breastfeeding and the TSST: The Regensburg Oxytocin Challenge (ROC) study
Jong, T. R. D., Menon, R., Bludau, A., Grund, T., Biermeier, V., Klampfl, S. M., Jurek, B., Bosch, O. J., Hellhammer, J., & Neumann, I. D. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.08.027 · Cited by 250
The human oxytocin gene promoter is regulated by estrogens
Richard, S., & Zingg, H. H. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39297-x · Cited by 242
Oxytocin facilitates protective responses to aversive social stimuli in males
Striepens, N., Scheele, D., Kendrick, K. M., Becker, B., Schäfer, L., Schwalba, K., Reul, J., Maier, W., & Hurlemann, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208852109 · Cited by 242
Effects of oxytocin on recollections of maternal care and closeness
Bartz, J. A., Zaki, J., Ochsner, K. N., Bolger, N., Kolevzon, A., Ludwig, N., & Lydon, J. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012669107 · Cited by 238 · cited 1×
“Similarly, anxiously attached individuals remembered their mothers as less caring and close following OT versus placebo, compared with securely attached individuals, who remembered their mothers as more caring and close in childhood following IN OT versus placebo.(170) Alternatively, some studies suggest utility of IN…”
Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers
Leng, G., & Sabatier, N. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12413 · Cited by 237 · cited 1×
“For example, there are large discrepancies in OT levels measured from unextracted and extracted plasma.(43) Values derived from unextracted samples have been found to be two orders of magnitude higher, likely because molecules besides OT are tagged and detected.”
Background
Oxytocin enhances processing of positive versus negative emotional information in healthy male volunteers
Di Simplicio, M., Massey-Chase, R., Cowen, P., & Harmer, C. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881108095705 · Cited by 229
The Role of Oxytocin in Human Affect: A Novel Hypothesis
Kemp, A. H., & Guastella, A. J. (2011) · Current Directions in Psychological Science · doi:10.1177/0963721411417547 · Cited by 228
Oxytocin influences processing of socially relevant cues in the ventral tegmental area of the human brain.
Groppe, S. E., Gossen, A., Rademacher, L., Hahn, A., Westphal, L., Gründer, G., & Spreckelmeyer, K. N. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.023 · Cited by 218
Association between childhood maltreatment and adult emotional dysregulation in a low-income, urban, African American sample: Moderation by oxytocin receptor gene
Bradley, B., Westen, D., Mercer, K. B., Binder, E. B., Jovanovic, T., Crain, D., Wingo, A., & Heim, C. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000162 · Cited by 213
Oxytocin facilitates the extinction of conditioned fear in humans
Eckstein, M., Becker, B., Scheele, D., Scholz, C., Preckel, K., Schlaepfer, T. E., Grinevich, V., Kendrick, K. M., Maier, W., & Hurlemann, R. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.10.015 · Cited by 210
Sensitivity to Intranasal Oxytocin in Adult Men with Early Parental Separation
Meinlschmidt, G., & Heim, C. C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.007 · Cited by 210
Oxytocin receptor genetic variation promotes human trust behavior
Krueger, F., Parasuraman, R., Iyengar, V., Thornburg, M., Weel, J., Lin, M., Clarke, E., McCabe, K., & Lipsky, R. H. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00004 · Cited by 207
The psychobiology of PTSD: Coping with trauma
Olff, M., Langeland, W., & Gersons, B. P. R. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.04.009 · Cited by 207
Self-citation
Oxytocin buffers cortisol responses to stress in individuals with impaired emotion regulation abilities
Quirin, M., Kuhl, J., & Düsing, R. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.12.005 · Cited by 204
Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex
Sripada, C. S., Phan, K. L., Labuschagne, I., Welsh, R., Nathan, P. J., & Wood, A. G. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000533 · Cited by 197
Oxytocin increases amygdala reactivity to threatening scenes in females
Lischke, A., Gamer, M., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., Herpertz, S. C., & Domes, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.01.011 · Cited by 194
Oxytocin increases anxiety to unpredictable threat
Grillon, C., Krimsky, M., Charney, D. R., Vytal, K., Ernst, M., & Cornwell, B. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.156 · Cited by 192 · cited 1×
“Additional studies of the effects of IN OT on threat perception in PTSD samples are needed, given its role in the development and maintenance of PTSD,(144) OT-related increases in salience processing,(94) and evidence that IN OT increases anxiety to unpredictable threat.(145) IN OT may also have distinct effects at di…”
Background
Intranasal oxytocin attenuates the cortisol response to physical stress: a dose-response study
Cardoso, C., Ellenbogen, M. A., Orlando, M. A., Bacon, S. L., & Joober, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.07.013 · Cited by 187
Oxytocin, the peptide that bonds the sexes also divides them
Gao, S., Becker, B., Luo, L., Geng, Y., Zhao, W., Yin, Y., Hu, J., Gao, Z., Gong, Q., Hurlemann, R., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602620113 · Cited by 186
Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men
Clodi, M., Vila, G., Geyeregger, R., Riedl, M., Stulnig, T. M., Struck, J., Luger, T. A., & Luger, A. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90263.2008 · Cited by 184
The effect of intranasal administration of oxytocin on fear recognition
Fischer-Shofty, M., Shamay-Tsoory, S. G., Harari, H., & Levkovitz, Y. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.09.003 · Cited by 184
Helping oxytocin deliver: considerations in the development of oxytocin-based therapeutics for brain disorders
MacDonald, K., & Feifel, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00035 · Cited by 181
Oxytocin increases recognition of masked emotional faces
Schulze, L., Lischke, A., Greif, J., Herpertz, S. C., Heinrichs, M., & Domes, G. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.03.011 · Cited by 180
Switching brain serotonin with oxytocin
Mottolese, R., Redouté, J., Costes, N., Le Bars, D., & Sirigu, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319810111 · Cited by 179
Neurophysiological effects of acute oxytocin administration: systematic review and meta-analysis of placebo-controlled imaging studies
Wigton, R., Radua, J., Allen, P., Averbeck, B., Meyer-Lindenberg, A., McGuire, P., Shergill, S. S., & Fusar-Poli, P. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130289 · Cited by 179
Making room for oxytocin in understanding depression
McQuaid, R. J., McInnis, O. A., Abizaid, A. B., & Anisman, H. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.005 · Cited by 175
Plasma oxytocin distributions in a large cohort of women and men and their gender-specific associations with anxiety
Weisman, O., Zagoory‐Sharon, O., Schneiderman, I., Gordon, I., & Feldman, R. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.08.011 · Cited by 175
A meta-analytic review of the impact of intranasal oxytocin administration on cortisol concentrations during laboratory tasks: Moderation by method and mental health
Cardoso, C., Kingdon, D., & Ellenbogen, M. A. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.07.014 · Cited by 171
An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits
Scheele, D., Kendrick, K. M., Khouri, C., Kretzer, E., Schläpfer, T. E., Stoffel-Wagner, B., Güntürkün, O., Maier, W., & Hurlemann, R. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.78 · Cited by 171
Intranasal administration of oxytocin: behavioral and clinical effects, a review
Veening, J. G., & Olivier, B. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.012 · Cited by 169
Effects of appraisal and coping on the neuroendocrine response to extreme stress
Olff, M., Langeland, W., & Gersons, B. P. R. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.12.006 · Cited by 160
Self-citation
Anxiolytic-like effect of oxytocin in the simulated public speaking test
de Oliveira, D. C., Zuardi, A. W., Graeff, F. G., Queiroz, R. H., & Crippa, J. A. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111400642 · Cited by 154
HPA- and HPT-axis alterations in chronic posttraumatic stress disorder
Olff, M., Güzelcan, Y., de Vries, G.-J., Assies, J., & Gersons, B. P. R. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.09.003 · Cited by 153
Self-citation
Bonding after trauma: on the role of social support and the oxytocin system in traumatic stress
Olff, M. (2012) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v3i0.18597 · Cited by 150
Self-citation
Effects of intranasal vasopressin and oxytocin on physiologic responding during personal combat imagery in Vietnam veterans with posttraumatic stress disorder
Pitman, R. K., Orr, S. P., & Lasko, N. B. (1993) · Psychiatry Research · doi:10.1016/0165-1781(93)90035-f · Cited by 150
Peripheral oxytocin and vasopressin: Biomarkers of psychiatric disorders? A comprehensive systematic review and preliminary meta-analysis
Rutigliano, G., Rocchetti, M., Paloyelis, Y., Gilleen, J., Sardella, A., Cappucciati, M., Palombini, E., Dell’Osso, L., Caverzasi, E., Politi, P., et al. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.04.117 · Cited by 149 · cited 1×
“A meta-analysis of 64 studies of several psychiatric disorders, including MDD but not PTSD, showed no significant differences in peripheral OT between healthy and psychiatric groups (except in anorexia).(40) Compared with trauma-exposed controls, lower peripheral OT levels have been observed in men, but not women, wit…”
Method
Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model
Quintana, D. S., Alvares, G. A., Hickie, I. B., & Guastella, A. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.011 · Cited by 149
Oxytocin in postnatally depressed mothers: Its influence on mood and expressed emotion
Mah, B. L., van IJzendoorn, M. H., Smith, R., & Bakermans‐Kranenburg, M. J. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.10.005 · Cited by 143
A general approach-avoidance hypothesis of Oxytocin: Accounting for social and non-social effects of oxytocin
Harari-Dahan, O., & Bernstein, A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.007 · Cited by 143
Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome
Hall, S. S., Lightbody, A. A., McCarthy, B. E., Parker, K. J., & Reiss, A. L. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.020 · Cited by 143
A heartfelt response: oxytocin effects on response to social stress in men and women
Kubzansky, L. D., Mendes, W. B., Appleton, A. A., Block, J., & Adler, G. K. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.02.010 · Cited by 142
The effect of intranasal oxytocin treatment on conditioned fear extinction and recall in a healthy human sample
Acheson, D., Feifel, D., de Wilde, S., Mckinney, R., Lohr, J., & Risbrough, V. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3099-4 · Cited by 141
Oxytocin and psychotherapy: a pilot study of its physiological, behavioral and subjective effects in males with depression
MacDonald, K., MacDonald, T. M., Brüne, M., Lamb, K., Wilson, M. P., Golshan, S., & Feifel, D. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.05.014 · Cited by 140
Oxytocin׳s role in anxiety: A critical appraisal
MacDonald, K., & Feifel, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.025 · Cited by 139
A psychobiological rationale for oxytocin in the treatment of posttraumatic stress disorder
Olff, M., Langeland, W., Witteveen, A., & Denys, D. (2010) · CNS Spectrums · doi:10.1017/s109285290000047x · Cited by 135
Self-citation
Intranasal Oxytocin to Prevent Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial in Emergency Department Patients
van Zuiden, M., Frijling, J. L., Nawijn, L., Koch, S. B. J., Goslings, J. C., Luitse, J. S., Biesheuvel, T. H., Honig, A., Veltman, D. J., & Olff, M. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.11.012 · Cited by 134
Self-citation
Intranasal Oxytocin Normalizes Amygdala Functional Connectivity in Posttraumatic Stress Disorder
Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.1 · Cited by 132
Self-citation
Oxytocin and Social Adaptation: Insights from Neuroimaging Studies of Healthy and Clinical Populations
Ma, Y., Shamay-Tsoory, S., Han, S., & Zink, C. F. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.10.009 · Cited by 131
Is there a Publication Bias in Behavioural Intranasal Oxytocin Research on Humans? Opening the File Drawer of One Laboratory
Lane, A., Luminet, O., Nave, G., & Mikolajczak, M. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12384 · Cited by 129
Aerosolized oxytocin increases cerebrospinal fluid oxytocin in rhesus macaques
Modi, M. E., Connor-Stroud, F., Landgraf, R., Young, L. J., & Parr, L. A. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.02.011 · Cited by 129
Oxytocin decreases handgrip force in reaction to infant crying in females without harsh parenting experiences
Bakermans‐Kranenburg, M. J., van IJzendoorn, M. H., Riem, M. M. E., Mattie Tops, A., & Alink, L. R. A. (2011) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr067 · Cited by 126
Intranasal oxytocin as strategy for medication-enhanced psychotherapy of PTSD: salience processing and fear inhibition processes
Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.11.018 · Cited by 123
Self-citation
Intranasal administration of oxytocin increases human aggressive behavior
Ne'eman, R., Perach-Barzilay, N., Fischer-Shofty, M., Atias, A., & Shamay-Tsoory, S. G. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.01.015 · Cited by 121
Hormonal contraceptives suppress oxytocin-induced brain reward responses to the partner’s face
Scheele, D., Plota, J., Stoffel-Wagner, B., Maier, W., & Hurlemann, R. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv157 · Cited by 116
Oxytocin indexes relational distress following interpersonal harms in women
Tabak, B. A., McCullough, M. E., Szeto, A., Mendez, A. J., & McCabe, P. M. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.07.004 · Cited by 116
Does the oxytocin receptor polymorphism (rs2254298) confer 'vulnerability' for psychopathology or 'differential susceptibility'? insights from evolution
Brüne, M. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-38 · Cited by 116
Does oxytocin influence the early detection of angry and happy faces?
Guastella, A. J., Carson, D. S., Dadds, M. R., Mitchell, P. B., & Cox, R. E. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.09.001 · Cited by 114
Oxytocin modulates the link between adult attachment and cooperation through reduced betrayal aversion
De Dreu, C. K. W. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.10.003 · Cited by 114
OxytocinSynthesis, Secretion, and Reproductive Functions
BURBACH, J., YOUNG, L., & RUSSELL, J. (2006) · Knobil and Neill's Physiology of Reproduction · doi:10.1016/b978-012515400-0/50063-4 · Cited by 113
Divergent effects of two different doses of intranasal oxytocin on facial affect discrimination in schizophrenic patients with and without polydipsia
Goldman, M. B., Gomes, A. M., Carter, C. S., & Lee, R. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2193-8 · Cited by 112
Oxytocin facilitates social approach behavior in women
Preckel, K., Scheele, D., Kendrick, K. M., Maier, W., & Hurlemann, R. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00191 · Cited by 111 · cited 11×
“Severity and course of MDD may also be meaningful qualifiers for use of IN OT.”
BackgroundInfluential
Plasma oxytocin is related to lower cardiovascular and sympathetic reactivity to stress
Grewen, K., & Light, K. C. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.04.003 · Cited by 107
Social anxiety, depression, and PTSD in Vietnam veterans
Hofmann, S. G., Litz, B. T., & Weathers, F. W. (2002) · Journal of Anxiety Disorders · doi:10.1016/s0887-6185(02)00227-x · Cited by 107
Association of Predeployment Gaze Bias for Emotion Stimuli With Later Symptoms of PTSD and Depression in Soldiers Deployed in Iraq
Beevers, C. G., Lee, H.-J., Wells, T. T., Ellis, A. J., & Telch, M. J. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10091309 · Cited by 106
Early life stress modulates oxytocin effects on limbic system during acute psychosocial stress
Grimm, S., Pestke, K., Feeser, M., Aust, S., Weigand, A., Wang, J., Wingenfeld, K., Pruessner, J. C., Marca, R. L., Böker, H., et al. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu020 · Cited by 106
Intranasal oxytocin and salivary cortisol concentrations during social rejection in university students
Linnen, A.-M., Ellenbogen, M. A., Cardoso, C., & Joober, R. (2012) · Stress · doi:10.3109/10253890.2011.631154 · Cited by 104
The influence of depressive symptomatology and perceived stress on plasma and salivary oxytocin before, during and after a support enhancement intervention
Holt-Lunstad, J., Birmingham, W., & Light, K. C. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.03.007 · Cited by 103
Boosting recovery rather than buffering reactivity: Higher stress-induced oxytocin secretion is associated with increased cortisol reactivity and faster vagal recovery after acute psychosocial stress
Engert, V., Koester, A. M., Riepenhausen, A., & Singer, T. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.08.029 · Cited by 103
Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial
Quintana, D. S., Westlye, L. T., Alnæs, D., Rustan, Ø. G., Kaufmann, T., Smerud, K. T., Mahmoud, R. A., Djupesland, P. G., & Andreassen, O. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.04.010 · Cited by 102
Menstrual cycle effects on psychological symptoms in women with PTSD
Nillni, Y. I., Pineles, S. L., Patton, S. C., Rouse, M. H., Sawyer, A. T., & Rasmusson, A. M. (2015) · Journal of Traumatic Stress · doi:10.1002/jts.21984 · Cited by 100
Acute intranasal oxytocin improves positive self-perceptions of personality
Cardoso, C., Ellenbogen, M. A., & Linnen, A.-M. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2527-6 · Cited by 98
Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients
Koch, S. B., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.299 · Cited by 98
Self-citation
When the Love Hormone Leads to Violence: Oxytocin Increases Intimate Partner Violence Inclinations Among High Trait Aggressive People
DeWall, C. N., Gillath, O., Pressman, S. D., Black, L. L., Bartz, J. A., Moskovitz, J., & Stetler, D. A. (2014) · Social Psychological and Personality Science · doi:10.1177/1948550613516876 · Cited by 96
Childhood maltreatment, juvenile disorders and adult post-traumatic stress disorder: a prospective investigation
Breslau, N., Koenen, K. C., Luo, Z., Agnew-Blais, J., Swanson, S., Houts, R. M., Poulton, R., & Moffitt, T. E. (2014) · Psychological Medicine · doi:10.1017/s0033291713002651 · Cited by 95
Oxytocin and Major Depressive Disorder: Experimental and Clinical Evidence for Links to Aetiology and Possible Treatment
Slattery, D. A., & Neumann, I. D. (2010) · Pharmaceuticals · doi:10.3390/ph3030702 · Cited by 94
Oxytocin effects on complex brain networks are moderated by experiences of maternal love withdrawal
Riem, M. M. E., van IJzendoorn, M. H., Tops, M., Boksem, M. A. S., Rombouts, S. A. R. B., & Bakermans-Kranenburg, M. J. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.01.011 · Cited by 91
Inverse effects of oxytocin on attributing mental activity to others in depressed and healthy subjects: a double-blind placebo controlled FMRI study
Pincus, D. (2010) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2010.00134 · Cited by 91
Gonadal Steroid Modulation of Stress-Induced Hypothalamo-Pituitary-Adrenal Activity and Anxiety Behavior: Role of Central Oxytocin
Windle, R. J., Gamble, L. E., Kershaw, Y. M., Wood, S. A., Lightman, S. L., & Ingram, C. D. (2006) · Endocrinology · doi:10.1210/en.2005-1079 · Cited by 90
Untitled work
Radke (2013) · doi:10.1177/0956797612472682 · Cited by 88
Oxytocin Facilitates Pavlovian Fear Learning in Males
Eckstein, M., Scheele, D., Patin, A., Preckel, K., Becker, B., Walter, A., Domschke, K., Grinevich, V., Maier, W., & Hurlemann, R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.245 · Cited by 87
Oxytocin’s effect on resting-state functional connectivity varies by age and sex
Ebner, N. C., Chen, H., Porges, E., Lin, T., Fischer, H., Feifel, D., & Cohen, R. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.03.013 · Cited by 84
The acute effects of intranasal oxytocin on automatic and effortful attentional shifting to emotional faces
Ellenbogen, M. A., Linnen, A., Grumet, R., Cardoso, C., & Joober, R. (2012) · Psychophysiology · doi:10.1111/j.1469-8986.2011.01278.x · Cited by 82
Association of Predeployment Gaze Bias for Emotion Stimuli With Later Symptoms of PTSD and Depression in Soldiers Deployed in Iraq
Beevers, C. G., Lee, H., Wells, T. T., Ellis, A. J., & Telch, M. J. (2011) · doi:10.21236/ada540417 · Cited by 78
Oxytocin increases willingness to socially share one's emotions
Lane, A., Luminet, O., Rimé, B., Gross, J. J., de Timary, P., & Mikolajczak, M. (2012) · International Journal of Psychology · doi:10.1080/00207594.2012.677540 · Cited by 76
Amygdala-Hippocampal Connectivity Changes During Acute Psychosocial Stress: Joint Effect of Early Life Stress and Oxytocin
Fan, Y., Pestke, K., Feeser, M., Aust, S., Pruessner, J. C., Böker, H., Bajbouj, M., & Grimm, S. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.123 · Cited by 75
Salivary Oxytocin and Vasopressin Levels in Police Officers With and Without Post‐Traumatic Stress Disorder
Frijling, J. L., van Zuiden, M., Nawijn, L., Koch, S. B. J., Neumann, I. D., Veltman, D. J., & Olff, M. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12300 · Cited by 74
Self-citation
The effect of oxytocin on attention to angry and happy faces in chronic depression
Domes, G., Normann, C., & Heinrichs, M. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-0794-9 · Cited by 73
Additional intranasal oxytocin to escitalopram improves depressive symptoms in resistant depression: An open trial
Scantamburlo, G., Hansenne, M., Geenen, V. G., Legros, J., & Ansseau, M. (2014) · European Psychiatry · doi:10.1016/j.eurpsy.2014.08.007 · Cited by 72
Intranasal oxytocin increases neural responses to social reward in post-traumatic stress disorder
Nawijn, L., van Zuiden, M., Koch, S. B. J., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw123 · Cited by 72
Self-citation
Oxytocin enhances attractiveness of unfamiliar female faces independent of the dopamine reward system
Striepens, N., Matusch, A., Kendrick, K. M., Mihov, Y., Elmenhorst, D., Becker, B., Lang, M., Coenen, H. H., Maier, W., Hurlemann, R., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.026 · Cited by 71
Differential Effects of Oxytocin on Agency and Communion for Anxiously and Avoidantly Attached Individuals
Bartz, J. A., Lydon, J. E., Kolevzon, A., Zaki, J., Hollander, E., Ludwig, N., & Bolger, N. (2015) · Psychological Science · doi:10.1177/0956797615580279 · Cited by 70
Residual Symptoms in Major Depressive Disorder: Prevalence, Effects, and Management
Zajecka, J., Kornstein, S. G., & Blier, P. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12059ah1 · Cited by 65
Effects of positive and negative human contacts and intranasal oxytocin on cerebrospinal fluid oxytocin
Rault, J. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.03.015 · Cited by 64
Effects of intranasal oxytocin on amygdala reactivity to emotional faces in recently trauma-exposed individuals
Frijling, J. L., van Zuiden, M., Koch, S. B. J., Nawijn, L., Veltman, D. J., & Olff, M. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv116 · Cited by 62
Self-citation
Failed Replication of Oxytocin Effects on Trust: The Envelope Task Case
Lane, A., Mikolajczak, M., Treinen, E., Samson, D., Corneille, O., de Timary, P., & Luminet, O. (2015) · PLOS ONE · doi:10.1371/journal.pone.0137000 · Cited by 60
Intranasal oxytocin enhances neural processing of monetary reward and loss in post-traumatic stress disorder and traumatized controls
Nawijn, L., van Zuiden, M., Koch, S. B. J., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.01.020 · Cited by 60
Self-citation
Intranasal oxytocin affects amygdala functional connectivity after trauma script-driven imagery in distressed recently trauma-exposed individuals
Frijling, J. L., van Zuiden, M., Koch, S. B. J., Nawijn, L., Veltman, D. J., & Olff, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.278 · Cited by 60
Self-citation
Effects of adverse childhood experiences on the association between intranasal oxytocin and social stress reactivity among individuals with cocaine dependence
Flanagan, J. C., Baker, N. L., McRae-Clark, A. L., Brady, K. T., & Moran-Santa Maria, M. M. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.07.064 · Cited by 56
Translating Oxytocin Neuroscience to the Clinic: A National Institute of Mental Health Perspective
Insel, T. R. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.02.002 · Cited by 56
PLASMA OXYTOCIN CONCENTRATION AND DEPRESSIVE SYMPTOMS: A REVIEW OF CURRENT EVIDENCE AND DIRECTIONS FOR FUTURE RESEARCH
Massey, S. H., Backes, K. A., & Schuette, S. (2016) · Depression and Anxiety · doi:10.1002/da.22467 · Cited by 53
Intranasal oxytocin impedes the ability to ignore task-irrelevant facial expressions of sadness in students with depressive symptoms
Ellenbogen, M. A., Linnen, A.-M., Cardoso, C., & Joober, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.06.016 · Cited by 53
Oxytocin effects on mind-reading are moderated by experiences of maternal love withdrawal: An fMRI study
Riem, M. M. E., Bakermans‐Kranenburg, M. J., Voorthuis, A., & van IJzendoorn, M. H. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.01.014 · Cited by 51
Social support, oxytocin, and PTSD
Olff, M., Koch, S. B. J., Nawijn, L., Frijling, J. L., Van Zuiden, M., & Veltman, D. J. (2014) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v5.26513 · Cited by 46
Self-citation
INTRANASAL OXYTOCIN ADMINISTRATION PRIOR TO EXPOSURE THERAPY FOR ARACHNOPHOBIA IMPEDES TREATMENT RESPONSE: Research Article: Intranasal Oxytocin Administration
Acheson, D. T., Feifel, D., Kamenski, M., Mckinney, R., & Risbrough, V. B. (2015) · Depression and Anxiety · doi:10.1002/da.22362 · Cited by 44
Oxytocin enhances attentional bias for neutral and positive expression faces in individuals with higher autistic traits
Xu, L., Ma, X., Zhao, W., Luo, L., Yao, S., & Kendrick, K. M. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.09.002 · Cited by 43
Oxytocin and Social Sensitivity: Gene Polymorphisms in Relation to Depressive Symptoms and Suicidal Ideation
McQuaid, R. J., McInnis, O. A., Matheson, K., & Anisman, H. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00358 · Cited by 42
Oxytocin and enhancement of the positive valence of social affiliation memories: An autobiographical memory study
Cardoso, C., Orlando, M. A., Brown, C. A., & Ellenbogen, M. A. (2014) · Social Neuroscience · doi:10.1080/17470919.2013.873079 · Cited by 38
Oxytocin and emotion processing
Simplicio, M. C. D., & Harmer, C. J. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116641872 · Cited by 38
Effects of couple interactions and relationship quality on plasma oxytocin and cardiovascular reactivity: Empirical findings and methodological considerations
Smith, T. W., Uchino, B. N., MacKenzie, J. J., Hicks, A. M., Campo, R., Reblin, M., Grewen, K., Amico, J. A., & Light, K. C. (2012) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2012.04.006 · Cited by 35
Plasma oxytocin in response to pharmaco-challenge to d-fenfluramine and placebo in healthy men
Lee, R., García, F., de Kar, L. D. V., Hauger, R., & Coccaro, E. F. (2003) · Psychiatry Research · doi:10.1016/s0165-1781(03)00070-2 · Cited by 34
Exploring Dissociation and Oxytocin as Pathways Between Trauma Exposure and Trauma-Related Hyperemesis Gravidarum: A Test-of-Concept Pilot
Seng, J. S., Miller, J. M., Sperlich, M. I., van de Ven, C. J. M., Brown, S. L., Carter, C. S., & Liberzon, I. (2013) · Journal of Trauma & Dissociation · doi:10.1080/15299732.2012.694594 · Cited by 33
P.3.026 Intranasal oxytocin in patients with post traumatic stress disorder: a single dose, pilot double blind crossover study
Yatzkar, U., & Klein, E. (2010) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(10)70098-5 · Cited by 32
Oxytocin and social context moderate social support seeking in women during negative memory recall
Cardoso, C., Valkanas, H., Serravalle, L., & Ellenbogen, M. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.05.001 · Cited by 29
Loss Of Trust: Correlates Of The Comorbidity Of Ptsd and Severe Mental Illness
Cias, C. M., Young, R., & Barreira, P. J. (2000) · Journal of Personal and Interpersonal Loss · doi:10.1080/10811440008409747 · Cited by 17
Fear or greed? Oxytocin regulates inter-individual conflict by enhancing fear in men
Zheng, H., Kendrick, K. M., & Yu, R. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.07.003 · Cited by 16
The neuropeptide oxytocin modulates consumer brand relationships
Fürst, A., Thron, J., Scheele, D., Marsh, N., & Hurlemann, R. (2015) · Scientific Reports · doi:10.1038/srep14960 · Cited by 14
Intranasal oxytocin: miracle cure after trauma?
Olff, M., van Zuiden, M., Koch, S. B. J., Nawijn, L., Frijling, J. L., & Veltman, D. J. (2015) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v6.27631 · Cited by 12
Self-citation
Interactive Effects Between Extraversion and Oxytocin Administration
Human, L. J., Thorson, K. R., & Mendes, W. B. (2016) · Social Psychological and Personality Science · doi:10.1177/1948550616644964 · Cited by 12
Psychosocial predator stress model of PTSD based on clinically relevant risk factors for trauma‐induced psychopathology
Zoladz, P. R., & Diamond, D. M. (2016) · Wiley eBooks · doi:10.1002/9781118356142.ch6 · Cited by 12
Examining the dimensionality of combat-related posttraumatic stress and depressive symptoms in treatment-seeking OEF/OIF/OND veterans
Tsai, J., Pietrzak, R. H., Southwick, S. M., & Harpaz‐Rotem, I. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.06.057 · Cited by 11
Self-citation
The potential of oxytocin as a therapeutic target for psychiatric disorders
Martinetz, S., & Neumann, I. D. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2016.1129403 · Cited by 9
An evolutionary perspective on oxytocin and its behavioral effects
Gangestad, S. W. (2015) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2015.08.016 · Cited by 8
Oxytocin and psychotherapy: Keeping context and person in mind
Cardoso, C., & Ellenbogen, M. A. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.08.002 · Cited by 8

Flagged first, then by citations

1 of the 204 references couldn’t be matched to a known paper.

Research works printed but not linked: 4

Macias CM, 2000, J Loss Trauma, 5, 103
Bartz JA, 2011, Trends Cogn Sci, 15, 301
10.1016/j.wpsyc.2012.01.003 · DOI
10.1016/j.psychres.2015.05.039 · DOI · Paper page

Sorted by citations

Handbook of Religion and Health
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · doi:10.1093/oso/9780190088859.001.0001 · Cited by 1,160
The Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder
Abdallah, C. G., Averill, L. A., Akiki, T. J., Raza, M., Averill, C. L., Gomaa, H., Adikey, A., & Krystal, J. H. (2018) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021701 · Cited by 179
Modelling resilience in adolescence and adversity: a novel framework to inform research and practice
Malhi, G. S., Das, P., Bell, E., Mattingly, G. W., & Mannie, Z. N. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0651-y · Cited by 161
Sex-dependent regulation of social reward by oxytocin: an inverted U hypothesis
Borland, J. M., Rilling, J. K., Frantz, K. J., & Albers, H. E. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0129-2 · Cited by 116
Emotional Transfer in Human–Horse Interaction: New Perspectives on Equine Assisted Interventions
Scopa, C., Contalbrigo, L., Greco, A., Lanatà, A., Scilingo, E. P., & Baragli, P. (2019) · Animals · doi:10.3390/ani9121030 · Cited by 114

See all 99

Authors: Sippel, L. M., Allington, C. E., Pietrzak, R. H., Harpaz-Rotem, I., Mayes, L. C., & Olff, M.
Affiliations: United States Department of Veterans Affairs (US)
VA Connecticut Healthcare System (US)
U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA
Yale University (US)
Amsterdam UMC Location University of Amsterdam (NL)
Corresponding author: Sippel, Lauren M.
ORCID: Sippel, Lauren M.
Pietrzak, Robert H.
Mayes, Linda C.
Olff, Miranda
Venue: Chronic Stress
Publisher: SAGE Publications
Published: 2017-02
Volume: 1
ISSN: 2470-5470 (ISSN-L)
DOI: 10.1177/2470547016687996
PMC: PMC5482285
OpenAlex: W2588660371
Cited by: 99
References: 204
Citations by year: 2026: 4 · 2025: 4 · 2024: 5 · 2023: 43 · 2022: 8 · 2021: 10 · 2020: 6 · 2019: 7 · 2018: 11 · 2017: 1
FWCI: 9.79
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Chronic Stress (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion, other-oa)
Europe PMC (PubMed Central) (acceptedVersion, cc-by-nc)
Data Archiving and Networked Services (DANS) (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institutes of Health (VA999999)
National Center for PTSD, U.S. Department of Veterans Affairs
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, stress-related psychiatric disorders, major depressive disorder, post-traumatic stress disorder, intranasal oxytocin, anhedonia, reward processing, fear and anxiety, social behavior, salience network, hypothalamic-pituitary-adrenal axis, child abuse, sex differences

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oxytocin and Stress-related Disorders: Neurobiological Mechanisms and Treatment Opportunities

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks