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A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
Open accessAbstract
The treatment of cultured rat-1 fibroblasts or H35 hepatoma cells with high concentrations of serum induces the circadian expression of various genes whose transcription also oscillates in living animals. Oscillating genes include rper1 and rper2 (rat homologs of the Drosophila clock gene period), and the genes encoding the transcription factors Rev-Erb alpha, DBP, and TEF. In rat-1 fibroblasts, up to three consecutive daily oscillations with an average period length of 22.5 hr could be recorded. The temporal sequence of the various mRNA accumulation cycles is the same in cultured cells and in vivo. The serum shock of rat-1 fibroblasts also results in a transient stimulation of c-fos and rper expression and thus mimics light-induced immediate-early gene expression in the suprachiasmatic nucleus.
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“circadian oscillators have been found in a number of peripheral tissues, such as liver, heart, lung, skeletal muscle, and adrenal glands [2, 3].”
From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [2]
In the citing paper
“it emerged that (almost) all cells in the body express the molecular machinery for the circadian clock.”
From Circadian control of glucose metabolism (2014) · cites this paper as [5]
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“We and others have shown that the molecular components of the peripheral clock mirror those of the SCN (Balsalobre et al., 1998; Zheng et al., 1999; Zylka et al., 1998)”
From Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. (2001) · cites this paper as Balsalobre et al., 1998
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Metadata
- Authors
- Balsalobre, A., Damiola, F., & Schibler, U.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Schibler, Ueli
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-06
- Volume
- 93
- Issue
- 6
- Pages
- 929-937
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2113297137
- Cited by
- 2,001
- References
- 47
- Citations by year
- 2026: 33 · 2025: 46 · 2024: 76 · 2023: 54 · 2022: 70 · 2021: 81 · 2020: 100 · 2019: 82 · 2018: 76 · 2017: 82 · 2016: 68 · 2015: 81 · 2014: 69 · 2013: 75 · 2012: 91
- FWCI
- 20.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- circadian gene expression, serum shock, clock genes, period gene, NR1D1, DBP, Rat-1 fibroblasts, c-fos, immediate early gene expression, suprachiasmatic nucleus, cell culture
- MeSH terms
- Animals, Biological Clocks, Blood, Cell Line, Circadian Rhythm, Cycloheximide, Fibroblasts, Gene Expression Regulation, Carcinoma, Hepatocellular, Liver, Nuclear Proteins, Protein Synthesis Inhibitors, RNA, Messenger, RNA, Neoplasm, Transcription Factors, Tumor Cells, Cultured, Genes, fos, Genes, Immediate-Early, Cell Cycle Proteins, Rats, Period Circadian Proteins
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